van Loghem Jani
Aesthet Surg J. 2025 Mar 17;45(4):393-403. doi: 10.1093/asj/sjae196.
Calcium hydroxylapatite-carboxymethylcellulose (CaHA-CMC) is a widely utilized soft tissue filler known for its compatibility with human tissue and for its effective volumizing properties. The biodegradable CaHA microspheres function as a scaffold for the formation of new tissue by stimulating a variety of cellular responses leading to the production of collagen, elastin, vasculature, and proteoglycans and thereby enhance skin quality. Despite the promising regenerative effects of CaHA-CMC, substantial gaps remain in understanding its precise underlying mechanisms, and addressing these gaps is crucial to optimizing its clinical applications. A literature search was conducted with PubMed, Google Scholar, and Web of Science for keywords, including "calcium hydroxylapatite," "tissue regeneration," "macrophages," "fibroblasts," and "calcium." This review elucidates the novel mechanisms of CaHA-CMC action within aesthetic medicine, with a focus on the dynamic interactions between macrophages and fibroblasts. The key role of calcium ions as critical biological cues in directing skin regeneration pathways is explored alongside an examination of the distinct physicochemical properties of CaHA-CMC. CaHA-CMC helps in tissue regeneration by providing calcium ions that act as key biological cues, promoting fibroblast activity and collagen production.
羟基磷灰石钙-羧甲基纤维素（CaHA-CMC）是一种广泛应用的软组织填充剂，以其与人体组织的相容性和有效的填充特性而闻名。可生物降解的CaHA微球通过刺激多种细胞反应，促进胶原蛋白、弹性蛋白、血管和蛋白聚糖的生成，从而形成新组织的支架，进而改善皮肤质量。尽管CaHA-CMC具有良好的再生效果，但在理解其确切的潜在机制方面仍存在很大差距，解决这些差距对于优化其临床应用至关重要。通过PubMed、谷歌学术和科学网对关键词进行文献检索，关键词包括“羟基磷灰石钙”、“组织再生”、“巨噬细胞”、“成纤维细胞”和“钙”。本综述阐明了CaHA-CMC在美容医学中的新作用机制，重点关注巨噬细胞与成纤维细胞之间的动态相互作用。探讨了钙离子作为指导皮肤再生途径的关键生物学信号的关键作用，并研究了CaHA-CMC独特的物理化学性质。CaHA-CMC通过提供作为关键生物学信号的钙离子来促进组织再生，促进成纤维细胞活性和胶原蛋白生成。
