通过宏基因组学从法属圭亚那一名病因不明的脑炎患者身上获得的与吸血蝙蝠相关的狂犬病病毒的全基因组序列。
Complete genome sequence of a vampire bat-related rabies virus obtained by metagenomics from a patient with encephalitis of unknown etiology, French Guiana.
作者信息
Hourdel Véronique, Balière Charlotte, Vanhomwegen Jessica, Brisebarre Angela, Grassin Quentin, Manuguerra Jean-Claude, Kallel Hatem, Demar Magalie, Dacheux Laurent, Caro Valérie
机构信息
Institut Pasteur, Université Paris Cité, Laboratory for Urgent Response to Biological Threats (CIBU), Environment and Infectious Risks (ERI) Unit, Paris, France.
Service de Réanimation Polyvalente, Centre Hospitalier de Cayenne, Cayenne, French Guiana.
出版信息
Microbiol Resour Announc. 2024 Nov 12;13(11):e0051424. doi: 10.1128/mra.00514-24. Epub 2024 Oct 4.
We report the complete genome sequence of a rabies virus obtained by direct metagenomics from the cerebellum of a gold panner who died of unknown encephalitis in French Guiana. Phylogenetic analysis exhibited a close genetic relationship with vampire bat-related isolates, confirming the second case of human rabies identified in this territory.
我们报告了一株狂犬病病毒的完整基因组序列，该病毒是通过直接宏基因组学方法从法属圭亚那一名死于不明脑炎的淘金者的小脑中获得的。系统发育分析显示，该病毒与吸血蝙蝠相关的分离株具有密切的遗传关系，证实了该地区确诊的第二例人类狂犬病病例。
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