Babu Kalpana, Chandana S, Tirumalai Aniruddha, Murthy Krishna R
Department of Uvea and Ocular Inflammation, Prabha Eye Clinic & Research Centre & Vittala International Institute of Ophthalmology, Bengaluru, India.
Department of Vitreoretinal Services, Prabha Eye Clinic & Research Centre & Vittala International Institute of Ophthalmology, Bengaluru, India.
Ocul Immunol Inflamm. 2025 Feb;33(2):317-319. doi: 10.1080/09273948.2024.2412215. Epub 2024 Oct 4.
We report a unique finding of iris nodules in a woman with endogenous endophthalmitis due to with no history of ocular surgery or trauma and good visual outcome.
MATERIALS & METHODS: Retrospective case report.
A 39-year-old woman with a history of type 2 diabetes mellitus presented with a decrease in vision in the right eye of 1-month duration. On examination, her BCVA was CF2m (OD) and 6/6 (OS). Right eye examination showed medium-to-large-sized keratic precipitates, iris nodules, and vitritis. PCR on the aqueous showed faint positivity for and was negative to panfungal genome. Despite two intravitreal injections of vancomycin (1 mg/0.1 ml) and intravenous cefazolin 1 g bd for 5 days, there was progression to hypopyon. Vitrectomy with lensectomy was done. The vitreous culture grew . She was given multiple intravitreal ceftazidime (2.25 mg/0.1 ml) with dexamethasone (0.4 mg/0.1 ml) injections. She was also put on tab bactrim DS twice a day for 3 months along with tab doxycycline 100 mg twice a day for 3 months by the infectious disease specialist. As the inflammation improved, the iris nodules were the last to resolve completely in 6 weeks. At 15-month follow-up, her eye was quiet, and vision was 6/9 (OD) with aphakic correction.
We report a rare finding of iris nodules in a patient with culture proven endogenous endophthalmitis.
