School of Health and Medical Sciences, University of Southern Queensland, Ipswich, QLD, Australia.
Respiratory and Exercise Physiology Research Group, School of Health and Medical Sciences, University of Southern Queensland, Ipswich, QLD, Australia.
Chron Respir Dis. 2024 Jan-Dec;21:14799731241289423. doi: 10.1177/14799731241289423.
COVID-19 patients experience respiratory muscle damage, leading to reduced respiratory function and functional capacity often requiring mechanical ventilation which further increases susceptibility to muscle weakness. Inspiratory muscle training (IMT) may help mitigate this damage and improve respiratory function and functional capacity. We studied the effects of IMT on muscle damage biomarkers, respiratory function, and functional capacity in COVID-19 recovered young adults, successfully weaned from mechanical ventilation. Participants were randomly allocated to either an IMT ( = 11) or control (CON; = 11) intervention for 4 weeks. The IMT group performed 30 dynamic inspiratory efforts twice daily, at 50% of their maximal inspiratory mouth pressure (P) while the CON group performed 60 inspiratory efforts at 10% of daily. Serum was collected at baseline, week two, and week four to measure creatine kinase muscle-type (CKM), fast skeletal troponin-I (sTnI) and slow sTnI. Time × group interaction effects were observed for CKM and slow sTnI, but not for fast sTnI. Both were lower at two and 4 weeks for the IMT compared to the CON group, respectively. Time × group interaction effects were observed for forced expiratory volume in 1s, forced vital capacity, P and right- and left-hand grip strength. These were higher for the IMT compared to the CON group. Four weeks of IMT decreased muscle damage biomarkers and increased respiratory function and grip strength in recovered COVID-19 patients after weaning from mechanical ventilation.
COVID-19 患者会出现呼吸肌损伤，导致呼吸功能和功能能力下降，常需机械通气，进一步增加肌肉无力的易感性。吸气肌训练（IMT）可能有助于减轻这种损伤，改善呼吸功能和功能能力。我们研究了 IMT 对 COVID-19 已康复、成功脱机的年轻成年人的肌肉损伤生物标志物、呼吸功能和功能能力的影响。参与者被随机分配到 IMT 组（n=11）或对照组（CON；n=11）进行 4 周的干预。IMT 组每天进行 2 次、每次 30 次的动态吸气努力，吸气口压力（P）的 50%；而 CON 组每天进行 60 次、10%P 的吸气努力。在基线、第 2 周和第 4 周采集血清，以测量肌酸激酶肌肉型（CKM）、快肌肌钙蛋白 I（sTnI）和慢肌 sTnI。观察到 CKM 和慢肌 sTnI 的时间×组间交互作用，但未观察到快肌 sTnI 的时间×组间交互作用。与 CON 组相比，IMT 组在第 2 周和第 4 周时分别降低了 CKM 和慢肌 sTnI。IMT 组的 1 秒用力呼气量、用力肺活量、P 和右手及左手握力的时间×组间交互作用均高于 CON 组。
