García-Beltrán Alejandro, Lozano Melero Aida, Martínez Martínez Rosario, Porres Foulquie Jesús María, López Jurado Romero de la Cruz María, Kapravelou Garyfallia
Department of Physiology, Biomedical Research Center, Instituto mixto de Deporte y Salud, University of Granada, 18007 Granada, Spain.
Department of Physiology, Faculty of Pharmacy, University of Granada, 18011 Granada, Spain.
Nutr Rev. 2025 May 1;83(5):819-841. doi: 10.1093/nutrit/nuae132.
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries and is strongly associated with several metabolic disorders. Plant-derived bioactive extracts, such as berry extracts, with high antioxidant capacity have been used for the treatment and prevention of this pathology. Moreover, they promote circular economy and sustainability.
To study the beneficial effects of extracts from different parts of berry plants in animal models of NAFLD.
A systematic research of the MEDLINE (via PubMed), Cochrane, and Scopus databases was conducted to identify relevant studies published after January 2011. In vivo animal studies of NAFLD were included in which berry extracts of different parts of the plant were administered and significantly improved altered biomarkers related to the pathology, such as lipid metabolism and hepatic steatosis, glucose and glycogen metabolism, and antioxidant and anti-inflammatory biomarkers.
Of a total of 203 articles identified, 31 studies were included after implementation of the inclusion and exclusion criteria.
Most of the studies showed a decrease in steatosis and a stimulation of genes related to β-oxidation and downregulation of lipogenic genes, with administration of berry extracts. Berry extracts also attenuated inflammation and oxidative stress.
Administration of berry extracts seems to have promising potential in the design of enriched foodstuffs or nutraceuticals for the treatment of NAFLD.
非酒精性脂肪性肝病（NAFLD）是西方国家慢性肝病的最常见病因，且与多种代谢紊乱密切相关。具有高抗氧化能力的植物源生物活性提取物，如浆果提取物，已被用于治疗和预防这种疾病。此外，它们还促进循环经济和可持续发展。
研究浆果植物不同部位的提取物在NAFLD动物模型中的有益作用。
对MEDLINE（通过PubMed）、Cochrane和Scopus数据库进行了系统检索，以识别2011年1月以后发表的相关研究。纳入了NAFLD的体内动物研究，其中给予植物不同部位的浆果提取物，并显著改善了与该疾病相关的改变的生物标志物，如脂质代谢和肝脂肪变性、葡萄糖和糖原代谢以及抗氧化和抗炎生物标志物。
在总共识别出的203篇文章中，在实施纳入和排除标准后纳入了31项研究。
大多数研究表明，给予浆果提取物后，脂肪变性减少，与β-氧化相关的基因受到刺激，脂肪生成基因下调。浆果提取物还减轻了炎症和氧化应激。
在设计用于治疗NAFLD的强化食品或营养保健品方面，给予浆果提取物似乎具有广阔的潜力。
