Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP, P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP, P.O. CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015, U.P., India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, U.P. 201002, India.
Eur J Med Chem. 2024 Dec 5;279:116915. doi: 10.1016/j.ejmech.2024.116915. Epub 2024 Sep 30.
Plants are rich in steroidal and triterpenoid saponins. Diosgenin is an important sapogenin obtained from various steroidal saponins and specially from dioscin. It possesses diverse pharmacological activities as it is capable of modulating various endogenous pathways. Diosgenin is the molecule of choice for the industrial synthesis of the steroid based clinical drugs namely progesterone, testosterone, dexamethasone, dehydroepiandrosterone, vitamin D, steroidal contraceptive pills, norethindrone, norgestrel etc. Diosgenin has been a molecule of discussion due to its high demand in industry as well as for future research applications. Present review describes its chemistry and detailed pharmacological profile.
植物富含甾体和三萜皂苷。薯蓣皂苷元是一种从各种甾体皂苷中特别从薯蓣皂苷中获得的重要皂苷元，具有多种药理学活性，因为它能够调节各种内源性途径。薯蓣皂苷元是甾体类临床药物如孕酮、睾酮、地塞米松、脱氢表雄酮、维生素 D、甾体避孕药、炔诺酮、去氧孕烯等的工业合成的首选分子。由于其在工业上的高需求以及未来的研究应用，薯蓣皂苷元一直是讨论的对象。本综述描述了其化学和详细的药理学概况。
