Department of Computational Biology, Institut Pasteur, Université Paris Cité, 25-28 Rue du Dr Roux, 75015 Paris, France.
Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.
Structure. 2024 Oct 3;32(10):1545-1547. doi: 10.1016/j.str.2024.09.003.
In this issue of Structure, Fan et al. report the structure of the full contactin 2 ectodomain, representing the first for the contactin family. The work reveals six immunoglobulin domains are essential for intercellular interactions, explores differences in proposed contactin 2 homodimerization mechanisms, and provides an updated model for contactin 2 organization on and between cells.
在本期《结构》杂志中,Fan 等人报告了完整的接触蛋白 2 胞外结构域的结构,这代表接触蛋白家族的首例。这项工作揭示了六个免疫球蛋白结构域对于细胞间相互作用是必需的,探讨了不同的接触蛋白 2 同源二聚化机制,并为接触蛋白 2 在细胞内外的结构提供了一个更新的模型。