Amsterdam UMC location Vrije Universiteit Amsterdam, Epidemiology and Data Science, the Netherlands.
Aging and Later Life, Amsterdam Public Health Research Institute, the Netherlands; Department of Health Sciences, Faculty of Science, Amsterdam Public Health Research Institute, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, the Netherlands.
Exp Gerontol. 2024 Nov;197:112599. doi: 10.1016/j.exger.2024.112599. Epub 2024 Oct 9.
The World Health Organization has introduced the construct of intrinsic capacity (IC) as an important component of healthy ageing and overall well-being in older adults The present study aimed to develop domain-specific and composite IC scores and to validate these scores by examining their longitudinal relation with functioning.
We used prospective data on participants aged 57 to over 90 years, with a 10-year follow-up, from the Longitudinal Aging Study Amsterdam, an ongoing cohort study of older Dutch men and women Using a formative, stepwise approach, we identified indicators across the different domains of IC, i.e. vitality, sensory, cognition, psychology, and locomotion, using a combination of unidimensional factor analyses and Partial Least Squares Structural Equation Modelling (PLS-SEM). Next, domain-specific and composite IC scores were generated, and the construct validity (score across age groups) and criterion validity (relationship with change in functional limitations) were assessed.
The multiple unidimensional factor analyses and PLS-SEM identified a total of 18 indicators, covering the five domains of IC. The mean composite IC score was 70.9 (SD = 0.9) in men and 69.7 (0.8) in women. The domain-specific and composite IC scores all showed good construct validity, with known-group validation results indicating age-related declines. A higher composite IC score was associated with less functional limitations over time (B = 0.20, 95%CI [0.19, 0.22]).
The developed domain-specific IC scores and the composite IC score effectively discriminated age-related declines in IC. Additionally, the composite IC score was longitudinally associated with functional limitations. By creating this comprehensive and reliable tool for tracking IC, we aim to provide valuable insights into the dynamics of ageing and support more effective strategies for promoting health and well-being throughout later life. These scores establish a foundation for future research to track longitudinal changes across various IC domains and relate these changes to key age-related outcomes.
世界卫生组织提出了内在能力（IC）的概念，将其作为老年人健康老龄化和整体福祉的一个重要组成部分。本研究旨在开发特定领域和综合 IC 评分，并通过检查其与功能的纵向关系来验证这些评分。
我们使用了来自阿姆斯特丹纵向老龄化研究的前瞻性数据，该研究是一项针对荷兰老年男女的正在进行的队列研究，参与者年龄在 57 岁以上，随访时间为 10 年。我们采用形成性、逐步的方法，使用一维因子分析和偏最小二乘结构方程建模（PLS-SEM）的组合，确定了内在能力不同领域的指标，即活力、感官、认知、心理和运动。接下来，生成了特定领域和综合 IC 评分，并评估了其结构效度（跨年龄组的评分）和效标效度（与功能限制变化的关系）。
多项一维因子分析和 PLS-SEM 共确定了 18 个指标，涵盖了内在能力的五个领域。男性的平均综合 IC 得分为 70.9（SD=0.9），女性为 69.7（0.8）。特定领域和综合 IC 评分均表现出良好的结构效度，通过已知组验证结果表明与年龄相关的下降。较高的综合 IC 评分与随着时间推移功能限制的减少相关（B=0.20，95%CI [0.19, 0.22]）。
所开发的特定领域内在能力评分和综合内在能力评分有效区分了内在能力的年龄相关下降。此外，综合内在能力评分与功能限制呈纵向相关。通过创建这个用于跟踪内在能力的综合和可靠工具，我们旨在为老龄化动态提供有价值的见解，并支持在以后的生活中更有效地促进健康和福祉的策略。这些评分为跟踪各个内在能力领域的纵向变化以及将这些变化与关键的年龄相关结果联系起来奠定了基础。
