Fairman Ciaran M, Kendall Kristina L, Newton Robert U, Hart Nicolas H, Taaffe Dennis R, Lopez Pedro, Chee Raphael, Tang Colin I, Galvão Daniel A
Exercise Medicine Research Institute, Edith Cowan University, Australia; Arnold School of Public Health, University of South Carolina, USA.
Exercise Medicine Research Institute, Edith Cowan University, Australia; School of Medical and Health Sciences, Edith Cowan University, Australia.
J Sci Med Sport. 2025 Feb;28(2):118-124. doi: 10.1016/j.jsams.2024.09.002. Epub 2024 Sep 14.
Androgen deprivation therapy (ADT) leads to loss of lean mass (LM) and reduced strength and physical function. Resistance exercise alone can counteract these changes; however, it is unknown if the addition of creatine supplementation can further protect against these ADT-induced toxicities. We compared the effects of creatine supplementation with resistance exercise versus resistance exercise alone in patients with prostate cancer undergoing ADT on LM, muscle strength, and physical function.
A 12-week randomized trial.
Men with prostate cancer receiving ADT (n = 30) were randomized to either resistance exercise + placebo (PLA) or resistance exercise + creatine (SUPP), with both groups undertaking supervised exercise 3 days per week. Outcomes included whole body and appendicular LM and fat mass (FM) assessed by dual-energy X-ray absorptiometry, as well as muscle strength (chest press, seated low, leg press), and physical function (timed up-and-go, chair rise, 400-m walk) assessed at baseline and following the intervention.
Patients were aged 59-84 years with a BMI of 28.6 kg·m. PLA completed a mean of 30 sessions (83 %) and SUPP a mean of 33 sessions (92 %). Despite similar within-group improvements (p < 0.05) in whole-body LM (PLA +0.6 kg, SUPP +1.3 kg), appendicular LM (PLA +0.5 kg, SUPP +0.6 kg), muscle strength (PLA +8.8-49.3 kg, SUPP +9.4-40.4 kg) and physical function, there were no between group differences (p = 0.078-0.951). No adverse events were reported due to creatine supplementation or resistance exercise.
A short-term program of resistance exercise alone results in meaningful improvements in LM, muscle strength and physical function, with no additional effects of creatine supplementation.
雄激素剥夺疗法（ADT）会导致去脂体重（LM）减少、力量和身体功能下降。单独进行抗阻运动可以抵消这些变化；然而，补充肌酸是否能进一步预防这些由ADT引起的毒性尚不清楚。我们比较了补充肌酸联合抗阻运动与单纯抗阻运动对接受ADT的前列腺癌患者的去脂体重、肌肉力量和身体功能的影响。
一项为期12周的随机试验。
接受ADT的前列腺癌男性患者（n = 30）被随机分为抗阻运动+安慰剂（PLA）组或抗阻运动+肌酸（SUPP）组，两组均每周进行3天有监督的运动。结果包括通过双能X线吸收法评估的全身和四肢去脂体重及脂肪量（FM），以及在基线和干预后评估的肌肉力量（卧推、坐姿低位、腿举）和身体功能（定时起立行走、从椅子上站起、400米步行）。
患者年龄在59 - 84岁之间，体重指数为28.6 kg·m²。PLA组平均完成30次训练（83%），SUPP组平均完成33次训练（92%）。尽管两组在全身去脂体重（PLA组增加0.6 kg，SUPP组增加1.3 kg）、四肢去脂体重（PLA组增加0.5 kg，SUPP组增加0.6 kg）、肌肉力量（PLA组增加8.8 - 49.3 kg，SUPP组增加9.4 - 40.4 kg）和身体功能方面组内改善相似（p < 0.05），但组间差异无统计学意义（p = 0.078 - 0.951）。未报告因补充肌酸或抗阻运动导致的不良事件。
仅进行短期抗阻运动计划就能显著改善去脂体重、肌肉力量和身体功能，补充肌酸无额外效果。
