血清尿酸水平与肺栓塞之间的关系：基于年龄的分层分析。
Relationship between serum uric acid levels and pulmonary embolism: an age-based stratified analysis.
作者信息
Yuan Bin, Song Lingyue, Su Weiqing, Zeng Xianbing, Su Jinqiang, Sun Jie, Wu Jun, Fu Kaili, Huang Zhihai, Chen Qiaoyun, Guo Dingyu, Sun Xishi, Pang Lingpin
机构信息
Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524000, Guangdong, China.
Lianjiang People's Hospital, Zhanjiang, 524400, Guangdong, China.
出版信息
Thromb J. 2024 Oct 4;22(1):87. doi: 10.1186/s12959-024-00655-y.
BACKGROUND
The association between uric acid and pulmonary embolism(PE) remains controversial, and there has been limited investigation into how uric acid influences pulmonary embolism across different age groups. Our study aimed to elucidate the relationship between uric acid levels and pulmonary embolism, considering variations across age groups.
METHODS
A total of 368 patients who underwent computed tomography pulmonary angiography from July 2018 to May 2022 were included in the analysis. Subsequently, the cohort was stratified by age, with separate univariate and multivariate logistic regression analyses conducted for the elderly (aged ≥ 60 years) and non-elderly (aged < 60 years), respectively.
RESULTS
The study revealed that patients with PE exhibited higher uric acid levels compared to those without (325.11 ± 137.02 vs. 298.26 ± 110.54 (umol/l), p = 0.039). This disparity persisted even after adjusting for multiple confounders (OR = 1.002, 95% CI 1.000-1.005, p = 0.042). Additionally, a notable age difference was observed between PE and non-PE patients (65.7 ± 16.12 vs. 61.42 ± 15.03 (umol/l), p = 0.009). Subsequently, upon age stratification, significant differences (p < 0.05) in serum uric acid were noted between PE and non-PE patients in both elderly and non-elderly populations. However, elevated uric acid levels were independently associated with PE only in the elderly following adjustment for multiple confounders (OR = 1.003, 95% CI 1.001-1.005, p = 0.008).
CONCLUSION
High uric acid levels are an independent risk factor for pulmonary embolism in the elderly (≥ 60 years).
背景
尿酸与肺栓塞（PE）之间的关联仍存在争议，并且关于尿酸如何在不同年龄组中影响肺栓塞的研究有限。我们的研究旨在阐明尿酸水平与肺栓塞之间的关系，并考虑年龄组之间的差异。
方法
分析纳入了2018年7月至2022年5月期间接受计算机断层扫描肺血管造影的368例患者。随后，根据年龄对队列进行分层，分别对老年人（年龄≥60岁）和非老年人（年龄<60岁）进行单因素和多因素逻辑回归分析。
结果
研究显示，与无肺栓塞的患者相比，肺栓塞患者的尿酸水平更高（325.11±137.02 vs. 298.26±110.54（umol/l），p = 0.039）。即使在调整多个混杂因素后，这种差异仍然存在（OR = 1.002，95%CI 1.000 - 1.005，p = 0.042）。此外，肺栓塞患者与非肺栓塞患者之间观察到显著的年龄差异（65.7±16.12 vs. 61.42±15.03（umol/l），p = 0.009）。随后，在年龄分层后，老年人和非老年人中肺栓塞患者与非肺栓塞患者的血清尿酸均存在显著差异（p<0.05）。然而，在调整多个混杂因素后，仅在老年人中尿酸水平升高与肺栓塞独立相关（OR = 1.003，95%CI 1.001 - 1.005，p = 0.008）。
结论
高尿酸水平是老年人（≥60岁）肺栓塞的独立危险因素。
Zotero 插件