Jain Shivani, Caire Haley, Haas Christopher J
Department of Dermatology, LSU Health Sciences Center-New Orleans School of Medicine, New Orleans, LA, USA.
Int J Dermatol. 2025 Mar;64(3):473-478. doi: 10.1111/ijd.17508. Epub 2024 Oct 4.
Dermatosis papulosa nigra (DPN) is a variant of seborrheic keratosis that typically presents as hyperpigmented pedunculated papules on the face, trunk, and/or back in those with skin of color. Although benign, the lesions can cause significant discomfort and distress. Management options are limited and often unaffordable, as treatment is elective in most cases. This study was undertaken to provide an updated summary of safe and efficacious treatments for DPN. Five databases were searched to identify full-text publications reporting on treatments and outcomes in adults with DPN. Seventeen publications met inclusion criteria and were included: six cohort studies, one randomized controlled trial, five case report studies, one case series, and four pilot studies. Treatment options included simple excision, curettage, electrodesiccation, cryotherapy, topicals, and laser therapies. These modalities varied in their documented outcomes and associated potential adverse effect profiles. Postinflammatory hyperpigmentation is a common adverse effect that often leads to patient dissatisfaction. It can be mitigated with topical treatments aimed at reducing local inflammation. Study limitations included small sample size in individual studies, lack of consistent reporting of Fitzpatrick skin type, and lack of comparison to the standard treatment of electrodesiccation or curettage. Ultimately, treatment should consider the patient's Fitzpatrick type, treatment area, associated costs, and potential adverse effects.
黑色丘疹性皮病（DPN）是脂溢性角化病的一种变体，通常表现为有色人种面部、躯干和/或背部出现色素沉着的带蒂丘疹。虽然病变是良性的，但会引起明显不适和困扰。治疗选择有限且往往费用高昂，因为大多数情况下治疗属于选择性的。本研究旨在提供关于DPN安全有效治疗方法的最新综述。检索了五个数据库，以确定报告成人DPN治疗及结果的全文出版物。17篇出版物符合纳入标准并被纳入：6项队列研究、1项随机对照试验、5项病例报告研究、1项病例系列研究和4项试点研究。治疗选择包括单纯切除、刮除术、电干燥法、冷冻疗法、局部用药和激光治疗。这些治疗方式在记录的结果和相关潜在不良反应方面各不相同。炎症后色素沉着是一种常见的不良反应，常导致患者不满意。可通过旨在减轻局部炎症的局部治疗来缓解。研究局限性包括个别研究样本量小、缺乏对Fitzpatrick皮肤类型的一致报告以及缺乏与电干燥法或刮除术标准治疗的比较。最终，治疗应考虑患者的Fitzpatrick类型、治疗部位、相关费用和潜在不良反应。
