一项前瞻性队列研究:战争期间分娩与产后抑郁、焦虑及母婴联结受损风险的关联
The association of delivery during a war with the risk for postpartum depression, anxiety and impaired maternal-infant bonding, a prospective cohort study.
作者信息
Klapper-Goldstein Hadar, Pariente Gali, Wainstock Tamar, Dekel Sharon, Binyamin Yair, Battat Talya Lanxner, Broder Orit Wissotzky, Kosef Tamar, Sheiner Eyal
机构信息
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
出版信息
Arch Gynecol Obstet. 2024 Dec;310(6):2863-2871. doi: 10.1007/s00404-024-07715-8. Epub 2024 Oct 5.
OBJECTIVE
To examine the impact of war conditions on maternal mental health postpartum outcomes, specifically depression and anxiety, as well as on maternal-infant bonding (MIB).
STUDY DESIGN
A prospective cohort study was performed on women who gave birth in a tertiary medical center during (October-November 2023) and before (March-May 2020) the Israel-Hamas War. All participants completed validated self-reported questionnaires: The Edinburgh Postnatal Depression Scale (EPDS ≥ 10), State-Trait Anxiety Inventory (STAI > 39) and the Postpartum Bonding Questionnaire (PBQ ≥ 26).
RESULTS
A total of 502 women were included in the study, with 230 delivering during the war and 272 delivered before. The rates of postpartum depression (PPD) were higher in women delivering during the war (26.6% vs. 12.4%, p < 0.001), while multivariable regression revealing a two-fold higher risk (adjusted OR 2.35, 95% CI 1.16-4.74, p = 0.017). The rate of postpartum anxiety (PPA) risk was also higher (34.3% vs 17.0%, p < 0.001), reaching a trend towards significance when accounting for other risk factors (adjusted OR 2.06, 95% CI 0.97-4.36, p = 0.058). Additionally, delivery during the war was associated with specific factors of impaired maternal-infant bonding (MIB), although it did not increase the overall impaired MIB (PBQ ≥ 26) (10.2 ± 14.1 vs 8.3 ± 6.9, p = 0.075).
CONCLUSION
The study revealed an increased risk of PPD, a marginally risk for PPA, and some aspects of impaired MIB among women delivering during the war. Maternal mental illness in the postpartum period has negative impacts on the entire family. Therefore, comprehensive screening and adequate resources should be provided for women delivering in war-conflict zones.
目的
探讨战争环境对产后母亲心理健康结局的影响,特别是对抑郁和焦虑的影响,以及对母婴联结(MIB)的影响。
研究设计
对在以色列-哈马斯战争期间(2023年10月至11月)和之前(2020年3月至5月)于一家三级医疗中心分娩的女性进行了一项前瞻性队列研究。所有参与者均完成了经过验证的自我报告问卷:爱丁堡产后抑郁量表(EPDS≥10)、状态-特质焦虑量表(STAI>39)和产后联结问卷(PBQ≥26)。
结果
共有502名女性纳入研究,其中230名在战争期间分娩,272名在战争前分娩。战争期间分娩的女性产后抑郁症(PPD)发生率更高(26.6%对12.4%,p<0.001),而多变量回归显示风险高出两倍(调整后OR 2.35,95%CI 1.16-4.74,p=0.017)。产后焦虑(PPA)风险发生率也更高(34.3%对17.0%,p<0.001),在考虑其他风险因素时达到显著趋势(调整后OR 2.06,95%CI 0.97-4.36,p=0.058)。此外,战争期间分娩与母婴联结受损的特定因素相关,尽管并未增加整体母婴联结受损(PBQ≥26)的情况(10.2±14.1对8.3±6.9,p=0.075)。
结论
该研究揭示了战争期间分娩的女性中PPD风险增加、PPA存在一定风险以及母婴联结受损的某些方面。产后母亲精神疾病会对整个家庭产生负面影响。因此,应为在战争冲突地区分娩的女性提供全面筛查和充足资源。