From the Pharmacy Practices Department, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
From the Public Health Centers, Makkah Healthcare Cluster, Makkah, Saudi Arabia.
Ann Saudi Med. 2024 Sep-Oct;44(5):296-305. doi: 10.5144/0256-4947.2024.296. Epub 2024 Oct 3.
Type 2 diabetes mellitus (T2DM) is a widespread chronic disease that poses a significant management challenge due to the complexity of the associated medication regimens, which can have a considerable impact on patient outcomes.
Explore the complexity level of diabetes medications among patients with T2DM and to identify the predictors of medication regimen complexity (MRC) and its correlation with hemoglobin A1C (HbA1c) levels.
Retrospective, cross-sectional study.
An ambulatory care setting of a tertiary hospital in Makkah City, Saudi Arabia.
Patients with T2DM referred to the diabetic clinic were identified and assessed for eligibility. The data were collected from patient electronic medical records between October 2022 and September 2023. The MRC Index was used to evaluate the complexity of the patients' medication regimens.
MRC index scores and HbA1c levels.
353 records of patients with T2DM.
The analysis revealed that 61.8% (n=218) of patients had high MRC, with the dosing frequency contributing significantly to their MRC (mean=3.9, SD=1.9). Having polypharmacy and longstanding T2DM were predictors of high MRC (odds ratios=4.9 and 2.6, respectively; ≤.01). Additionally, there was an inverse association between the patients' diabetes-specific MRC index scores and their glycemic control (odds ratios=0.2, <.001).
The study findings highlight the importance of considering MRC in managing T2DM. Simplifying medication regimens and optimizing medication management strategies can improve patient outcomes. Further research is needed to explore interventions to reduce MRC and enhance diabetes management in this population.
Retrospective study design measuring the MRC at a diabetes-specific level.
2 型糖尿病（T2DM）是一种广泛存在的慢性疾病，由于相关药物治疗方案的复杂性，给患者的管理带来了重大挑战，这可能会对患者的结局产生重大影响。
探究 T2DM 患者的糖尿病药物治疗复杂性（MRC）水平，并确定预测 MRC 及其与糖化血红蛋白（HbA1c）水平相关性的因素。
回顾性、横断面研究。
沙特阿拉伯麦加市的一家三级医院的门诊环境。
鉴定并评估了 2022 年 10 月至 2023 年 9 月期间在糖尿病诊所就诊的 T2DM 患者是否符合纳入标准。从患者的电子病历中收集数据。使用 MRC 指数评估患者药物治疗方案的复杂性。
MRC 指数评分和 HbA1c 水平。
353 例 T2DM 患者的记录。
分析显示，61.8%（n=218）的患者 MRC 较高，其中剂量频率对其 MRC 有显著影响（平均值=3.9，标准差=1.9）。合并用药和长期 T2DM 是 MRC 较高的预测因素（比值比分别为 4.9 和 2.6；均≤.01）。此外，患者糖尿病特异性 MRC 指数评分与血糖控制呈负相关（比值比为 0.2，<.001）。
研究结果强调了在管理 T2DM 时考虑 MRC 的重要性。简化药物治疗方案和优化药物管理策略可以改善患者的结局。需要进一步研究探索干预措施，以降低 MRC 并改善该人群的糖尿病管理。
回顾性研究设计，仅测量了糖尿病特定水平的 MRC。
