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咽鼓管异常开放症的诊断与治疗

Diagnosis and treatment of patulous eustachian tube.

作者信息

Ikeda Ryoukichi

机构信息

Department of Otolaryngology-Head-Neck Surgery, Iwate Medical University School of Medicine, 2-1-1 Idai dori, Yahaba, Iwate 028-3695, Japan.

出版信息

Auris Nasus Larynx. 2024 Dec;51(6):947-955. doi: 10.1016/j.anl.2024.09.007. Epub 2024 Oct 4.

Abstract

Symptoms of patulous Eustachian Tube (PET) were first described by Jago in 1858 and reported by Schwartze in 1864, recognizing PET as a clinical entity. This review summarizes the causes, epidemiology, diagnosis, and treatment of PET, with a particular emphasis on diagnosis and treatment, detailing the diagnostic criteria and silicone plug (Kobayashi plug) surgery proposed or developed in Japan. PET is often linked to weight loss from chronic illnesses, dieting, anorexia nervosa, hemodialysis, and bariatric surgery. It is also associated with pregnancy, oral contraceptive use, nasopharyngeal and muscular atrophy or scarring, and neuromuscular diseases. Interestingly, many PET cases lack an identifiable cause. The prevalence of PET ranges from 0.3 % to 7.0 %, with a higher incidence in females and typically occurring in adolescents and adults. Diagnosis relies on a combination of clinical history, physical examination, ET function test, and imaging. The Japan Otological Society (JOS) proposed standardized diagnostic criteria, where a "definite PET" diagnosis requires all three criteria (aural symptoms, tubal obstruction procedures, and objective findings), while "possible PET" requires two. Treatment includes conservative and surgical interventions. For persistent and severe cases that do not improve with conservative treatments, surgical options are explored. These surgical procedures are classified by the type of intervention, which includes tympanic membrane manipulation (such as tympanostomy tube insertion and mass loading of the tympanic membrane), plug surgery, ET injection, shim surgery, tuboplasty, and ET closure. The Kobayashi plug, a 23 mm long silicone plug, is specifically designed for PET treatment. Indications for its use include "definite PET," a PHI-10 score of 26 or higher, and lack of improvement after six months of conservative treatment. Preoperative evaluations include CT scans to assess ET patency and confirm the bony portion. Surgery, mostly performed under local anesthesia, involves inserting the plug into the ET via a myringotomy, ensuring the correct size and position with endoscopic guidance. In conclusion, PET is a challenging condition with diverse etiologies and symptoms. Effective management requires a comprehensive diagnostic approach and tailored treatment plans, with the Kobayashi plug offering a promising solution for refractory cases. Further research and advancements in diagnostic techniques and therapeutic interventions will continue to enhance the management of PET.

摘要

咽鼓管异常开放(PET)的症状最早由贾戈于1858年描述,并由施瓦策于1864年报道,从而将PET确认为一种临床病症。本综述总结了PET的病因、流行病学、诊断和治疗,特别强调诊断和治疗,详细介绍了日本提出或研发的诊断标准和硅胶栓(小林栓)手术。PET常与慢性病导致的体重减轻、节食、神经性厌食症、血液透析和减肥手术有关。它还与妊娠、口服避孕药的使用、鼻咽部和肌肉萎缩或瘢痕形成以及神经肌肉疾病有关。有趣的是,许多PET病例缺乏可识别的病因。PET的患病率在0.3%至7.0%之间,女性发病率较高,通常发生在青少年和成年人中。诊断依赖于临床病史、体格检查、咽鼓管功能测试和影像学检查相结合。日本耳科学会(JOS)提出了标准化的诊断标准,“确诊PET”诊断需要满足所有三个标准(耳部症状、咽鼓管阻塞检查和客观检查结果),而“可能PET”需要满足两个标准。治疗包括保守治疗和手术干预。对于保守治疗无效的持续性严重病例,探索手术选择。这些手术程序按干预类型分类,包括鼓膜操作(如鼓膜置管和鼓膜负重)、栓塞手术、咽鼓管注射、垫片手术、咽鼓管成形术和咽鼓管闭合术。小林栓是一种23毫米长的硅胶栓,专门为PET治疗设计。其使用指征包括“确诊PET”、PHI - 10评分26分或更高以及保守治疗六个月后无改善。术前评估包括CT扫描以评估咽鼓管通畅情况并确认骨质部分。手术大多在局部麻醉下进行,通过鼓膜切开术将栓子插入咽鼓管,在内镜引导下确保尺寸和位置正确。总之,PET是一种病因和症状多样的具有挑战性的病症。有效的管理需要全面的诊断方法和量身定制的治疗方案,小林栓为难治性病例提供了一种有前景的解决方案。诊断技术和治疗干预的进一步研究和进展将继续改善PET的管理。

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