Universitat Rovira i Virgili, Department of Analytical Chemistry and Organic Chemistry, Sescelades Campus Building N4, Marcel⋅lí Domigo, 1, 43007, Tarragona, Spain; Universitat Rovira i Virgili, Department of Electrical and Automatic control Engineering, Sescelades Campus Building E4, Av. Països Catalans, 26, 43007, Tarragona, Spain.
Institut d'Investigació Sanitària Pere Virgili, Excorxador, s/n, 43007, Tarragona, Spain; Universitat Rovira i Virgili, Paediatrics Research Unit, Nutrition & Human Development, Sescelades Campus Building E4, Països Catalans, 26, 43007, Tarragona, Spain.
Environ Res. 2024 Dec 15;263(Pt 2):120107. doi: 10.1016/j.envres.2024.120107. Epub 2024 Oct 4.
High production volume chemicals (HPVCs) and polycyclic aromatic hydrocarbons (PAHs) are semi-volatile organic compounds (semi-VOCs) of great environmental concern because of their presence worldwide and health problems resulting from long-term exposure to some of them. It is essential to have robust analytical methods to monitor the concentrations of these compounds not only in environmental samples but also individual exposure. In this pilot study we develop and validate a multiresidue analytical method based on ultrasound-assisted extraction and gas-chromatography mass spectrometry for the simultaneous determination of 56 semi-VOCs using silicone wristbands (SWBs) as personal passive samplers. The developed method provided recoveries between 43% and 114% on sampled SWBs and method detection and quantification limits in the range of 0.1-35 ng/g and 0.3-119 ng/g, respectively. A preliminary study was performed with a small group of adults living in the industrial city of Tarragona (north-eastern Spain) to evaluate the applicability of SWBs for monitoring individual exposure to the studied HPVCs and PAHs. Benzothiazoles, benzenesulfonamides, UV stabilisers and phenolic antioxidants were determined for the first time in SWBs. Phthalates (PAEs), stood out above the rest, accounting for 52% of the total concentrations. Diethylhexyl phthalate was the compound found at the highest concentrations with values between 1.1 and 82 μg/g. Carcinogenic and non-carcinogenic dermal risk assessment was performed for adults and considering two scenarios (low and high). PAHs were the compounds with the highest carcinogenic and non-carcinogenic dermal risk regardless of the exposure scenario. The second family of compounds that contributed the most to the total risk were PAEs but high punctual concentrations of these compounds caused significant differences between exposure scenarios.
高生产量化学物质（HPVCs）和多环芳烃（PAHs）是具有重大环境关注的半挥发性有机化合物（semi-VOCs），因为它们在全球范围内存在，并且长期暴露于其中一些物质会导致健康问题。拥有强大的分析方法来监测这些化合物的浓度至关重要，不仅要监测环境样本中的浓度，还要监测个体暴露的浓度。在本试点研究中，我们开发并验证了一种基于超声波辅助提取和气相色谱-质谱联用的多残留分析方法，用于使用硅酮腕带（SWB）作为个人被动采样器同时测定 56 种半挥发性有机化合物。开发的方法在采样的 SWB 上提供了 43%至 114%的回收率，方法检测限和定量限分别在 0.1-35ng/g 和 0.3-119ng/g 的范围内。对居住在西班牙东北部工业城市塔拉戈纳的一小群成年人进行了初步研究，以评估 SWB 监测研究的 HPVCs 和 PAHs 个体暴露的适用性。首次在 SWB 中测定了苯并噻唑、苯磺酰胺、紫外线稳定剂和酚类抗氧化剂。邻苯二甲酸酯（PAEs）比其他物质更为突出，占总浓度的 52%。二乙基己基邻苯二甲酸酯是发现浓度最高的化合物，浓度在 1.1 至 82μg/g 之间。对成人进行了致癌和非致癌皮肤风险评估，并考虑了两种情况（低和高）。无论暴露情况如何，PAHs 都是具有最高致癌和非致癌皮肤风险的化合物。对总风险贡献最大的第二类化合物是 PAEs，但这些化合物的高浓度会导致暴露情况之间存在显著差异。
