Özgen Alpaydin Aylin, Uçan Eyüp Sabri, Köktürk Mine, Atamanalp Muhammed, Kalyoncu Çisem, Yiğit Salih, Uçar Arzu, Şimşek Gökçen Ömeroğlu, Tertemiz Kemal Can, Karaçam Volkan, Ulukuş Elif Çağnur, Gürel Duygu, Alak Gonca
Dokuz Eylül University Faculty of Medicine, Department of Pulmonary Diseases, Izmir, Turkey.
Dokuz Eylül University Faculty of Medicine, Department of Pulmonary Diseases, Izmir, Turkey.
Environ Pollut. 2024 Dec 15;363(Pt 1):125054. doi: 10.1016/j.envpol.2024.125054. Epub 2024 Oct 4.
Microplastic (MPs) pollution is a global concern that affects all living organisms, yet research on MP-related disorders in humans, including incidence and symptoms, remains limited. In this study, the presence, composition, and characterization of MPs in bronchoalveolar lavage (BAL), which reflects lung tissue, and blood were examined. Fiberoptic bronchoscopy was performed to collect BAL samples from patients suspected of having interstitial lung disease (ILD) as well as from a control group. MPs were identified and measured using μ-Raman techniques. In BAL samples, the most common MPs color observed was grey/white, with sizes ranging from 4.19 to 792.00 μm. The particle shapes and polymer types identified included polyamide (PA), polyester (PET), polyvinyl chloride (PVC), and polyurethanes (PU). For blood samples, MPs were predominantly grey/white and blue, with sizes ranging from 13.14 to 20. 29 μm. The identified polymers in blood samples included polyamide (PA) and polyethylene (PE). MPs were detected in 10 out of 18 patients (55%) suspected of having ILD, with most of these patients presenting with the fibrotic type of the disease. In the control group, two patients whose BAL samples were positive for MPs were found to have chronic lung disease. This study is the first to explore the relationship between interstitial lung disease (ILD) and microplastics (MPs), revealing a tendency for the presence of MPs in the bronchoalveolar lavage (BAL) of ILD patients, particularly those with a fibrotic phenotype. Further research is needed to determine the cumulative effects of MPs on human health, especially concerning the respiratory system, which is highly exposed to environmental pollutants.
微塑料（MPs）污染是一个全球关注的问题，影响着所有生物，但关于人类与微塑料相关疾病的研究，包括发病率和症状，仍然有限。在本研究中，对反映肺组织的支气管肺泡灌洗（BAL）和血液中的微塑料的存在、组成和特征进行了检查。对疑似患有间质性肺病（ILD）的患者以及对照组进行了纤维支气管镜检查以收集BAL样本。使用μ-拉曼技术鉴定和测量微塑料。在BAL样本中，观察到的最常见的微塑料颜色为灰色/白色，尺寸范围为4.19至792.00μm。鉴定出的颗粒形状和聚合物类型包括聚酰胺（PA）、聚酯（PET）、聚氯乙烯（PVC）和聚氨酯（PU）。对于血液样本，微塑料主要为灰色/白色和蓝色，尺寸范围为13.14至20.29μm。血液样本中鉴定出的聚合物包括聚酰胺（PA）和聚乙烯（PE）。在18名疑似患有ILD的患者中，有10名（55%）检测到微塑料，其中大多数患者表现为纤维化类型的疾病。在对照组中，发现两名BAL样本微塑料呈阳性的患者患有慢性肺病。本研究首次探讨了间质性肺病（ILD）与微塑料（MPs）之间的关系，揭示了ILD患者支气管肺泡灌洗（BAL）中存在微塑料的趋势，特别是那些具有纤维化表型的患者。需要进一步研究以确定微塑料对人类健康的累积影响，特别是关于呼吸系统，因为呼吸系统高度暴露于环境污染物。
