Rizzo Giacomo Emanuele Maria, Traina Mario, Ligresti Dario, Carrozza Lucio, Rancatore Gabriele, Liotta Rosa, Bertani Alessandro, Tarantino Ilaria
Endoscopy Service, Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione, University of Pittsburgh Medical Center Italy, Palermo, Italy; Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, Palermo, Italy.
Endoscopy Service, Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione, University of Pittsburgh Medical Center Italy, Palermo, Italy.
Gastrointest Endosc. 2025 Feb;101(2):436-440.e3. doi: 10.1016/j.gie.2024.09.042. Epub 2024 Oct 4.
Pulmonary masses are a diagnostic challenge in the field of EUS tissue acquisition, especially through transesophageal EUS-guided fine-needle biopsy sampling (EUS-FNB). Our study evaluated the feasibility, diagnostic performance, and safety of EUS-FNB of pulmonary lesions.
Fifty-three patients were enrolled in a prospective registry. All EUS procedures were performed by experienced endosonographers. Outcomes were specimen adequacy, diagnostic accuracy, diagnostic sensibility, diagnostic specificity, and safety.
The mean patient age was 70 ± 10.4 years, and 71.7% were men. The mean lesion size was 52.4 ± 23.3 mm, and patients mostly had a single lesion (86.8%). Most patients had an advanced stage at diagnosis (stage IV, 41.82%), and the most common lung cancer was non-small cell lung carcinoma (69.4%). The diagnostic adequacy rate was 92.86%, and diagnostic accuracy was 87.5%. Adverse events were reported in 3 procedures.
Transesophageal EUS-FNB is a feasible and safe diagnostic method of tissue sampling for lung masses reachable by EUS.
在超声内镜引导下的组织获取领域，肺部肿块的诊断具有挑战性，尤其是经食管超声内镜引导下细针穿刺活检采样（EUS-FNB）。我们的研究评估了EUS-FNB对肺部病变的可行性、诊断性能及安全性。
53例患者被纳入前瞻性登记研究。所有超声内镜检查均由经验丰富的超声内镜医师进行。观察指标包括标本充足率、诊断准确性、诊断敏感性、诊断特异性及安全性。
患者的平均年龄为70±10.4岁，男性占71.7%。病变的平均大小为52.4±23.3mm，大多数患者有单个病变（86.8%）。大多数患者诊断时处于晚期（IV期，41.82%），最常见的肺癌类型为非小细胞肺癌（69.4%）。诊断充足率为92.86%，诊断准确性为87.5%。3例操作出现不良事件。
经食管EUS-FNB是一种可行且安全的诊断方法，可用于对EUS可及的肺部肿块进行组织采样。
