Dalton Juliet C, Thomas Samantha M, Chiba Akiko, Wang Ton, Hwang E Shelley, Plichta Jennifer K
Department of Surgery, Duke University Medical Center, 2301 Erwin Rd, Durham, NC 27707, USA.
Duke Cancer Institute, Duke University, 10 Bryan Searle Drive, Durham, NC 27710, USA; Department of Biostatistics and Bioinformatics, Duke University, 40 Duke Medicine Circle, Durham, NC 27710, USA.
Am J Surg. 2025 Jan;239:115993. doi: 10.1016/j.amjsurg.2024.115993. Epub 2024 Sep 27.
Breast atypia increases overall breast cancer risk, potentially necessitating future interventions. This study examines the frequency and outcomes of additional percutaneous biopsies after an atypia diagnosis.
Adult patients with breast atypia (atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ) at a single institution were reviewed for subsequent core needle biopsies (CNBs) and corresponding malignant outcomes.
Among 432 patients, median age at diagnosis was 54.8 y. Seventy-one (71/432, 16.4 %) patients developed a breast malignancy. During a median follow-up of 7.4 y, 113 patients underwent 149 additional CNBs. Twenty-six patients (26/113, 23.0 %) had >2 additional CNBs. Approximately half (79/149, 53.0 %) of all additional CNBs occurred within 5 years after breast atypia diagnosis.
A considerable number of patients with breast atypia undergo additional percutaneous biopsies, especially within 5 years post-atypia diagnosis. Our study highlights the significant burden of surveillance and the need for tailored follow-up strategies.
乳腺非典型增生会增加总体乳腺癌风险，可能需要未来进行干预。本研究调查了非典型增生诊断后额外经皮活检的频率和结果。
回顾了单一机构中患有乳腺非典型增生（非典型导管增生、非典型小叶增生、小叶原位癌）的成年患者的后续粗针活检（CNB）及相应的恶性结果。
在432例患者中，诊断时的中位年龄为54.8岁。71例（71/432，16.4%）患者发生了乳腺恶性肿瘤。在中位随访7.4年期间，113例患者接受了149次额外的粗针活检。26例患者（26/113，23.0%）接受了超过2次额外的粗针活检。所有额外粗针活检中约一半（79/149，53.0%）发生在乳腺非典型增生诊断后的5年内。
相当数量的乳腺非典型增生患者接受了额外的经皮活检，尤其是在非典型增生诊断后的5年内。我们的研究突出了监测的重大负担以及制定个性化随访策略的必要性。
