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精准医学社会责任使用的系统决策框架。

Systematic decision frameworks for the socially responsible use of precision medicine.

作者信息

Peebles Ian S, Kinney David B, Foster-Hanson Emily

机构信息

School of Historical, Philosophical and Religious Studies, Arizona State University, Tempe, AZ, USA.

Department of Philosophy and Program in Philosophy-Neuroscience-Psychology, Washington University in St. Louis, St. Louis, MO, USA.

出版信息

NPJ Genom Med. 2024 Oct 5;9(1):46. doi: 10.1038/s41525-024-00433-9.

DOI:10.1038/s41525-024-00433-9
PMID:39369024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11455903/
Abstract

Deep learning techniques and whole-genome sequencing promise to increase well-being but also risk perpetuating psychological essentialism, potentially justifying inequality. In this Comment, we offer two much-needed systematic frameworks for clinicians and researchers to avoid essentialist inferences and unfair treatment: (1) a data-driven method for detecting causal fairness in precision health and (2) an ethical framework for determining when it is morally permissible to use racial classifications in population health research.

摘要

深度学习技术和全基因组测序有望增进福祉,但也有延续心理本质主义的风险,这可能会使不平等现象合理化。在这篇评论文章中,我们为临床医生和研究人员提供了两个急需的系统框架,以避免本质主义推断和不公平待遇:(1)一种用于检测精准医疗中因果公平性的数据驱动方法,以及(2)一个用于确定在人群健康研究中何时在道德上允许使用种族分类的伦理框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8c0/11455903/8c6c146ef8d0/41525_2024_433_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8c0/11455903/8c6c146ef8d0/41525_2024_433_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8c0/11455903/8c6c146ef8d0/41525_2024_433_Fig1_HTML.jpg

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本文引用的文献

1
'All of Us' genetics chart stirs unease over controversial depiction of race.“我们所有人”基因图谱引发对种族争议性描绘的不安。
Nature. 2024 Feb 23. doi: 10.1038/d41586-024-00568-w.
2
A systemic approach to the psychology of racial bias within individuals and society.一种针对个体和社会中种族偏见心理的系统方法。
Nat Rev Psychol. 2023 May 18:1-15. doi: 10.1038/s44159-023-00190-z.
3
Clinical and Genetic Characteristics of CKD Patients with High-Risk APOL1 Genotypes.具有高危 APOL1 基因型的 CKD 患者的临床和遗传特征。
J Am Soc Nephrol. 2023 May 1;34(5):909-919. doi: 10.1681/ASN.0000000000000094. Epub 2023 Feb 9.
4
Counter the weaponization of genetics research by extremists.对抗极端分子将基因研究武器化的行为。
Nature. 2022 Oct;610(7932):444-447. doi: 10.1038/d41586-022-03252-z.
5
Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease.肾小球疾病患者急性护理利用中的种族和民族差异。
Am J Kidney Dis. 2023 Mar;81(3):318-328.e1. doi: 10.1053/j.ajkd.2022.08.010. Epub 2022 Oct 1.
6
Housing: A Critical Contributor to Kidney Disease Disparities.住房:肾病差异的关键促成因素。
J Am Soc Nephrol. 2022 Aug;33(8):1471-1473. doi: 10.1681/ASN.2022040424. Epub 2022 May 11.
7
The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.载脂蛋白 L1 肾病的演变故事:开端的结束。
Nat Rev Nephrol. 2022 May;18(5):307-320. doi: 10.1038/s41581-022-00538-3. Epub 2022 Feb 25.
8
Conceptualizing, Contextualizing, and Operationalizing Race in Quantitative Health Sciences Research.将种族概念化、情境化和操作化在定量健康科学研究中。
Ann Fam Med. 2022 Mar-Apr;20(2):157-163. doi: 10.1370/afm.2792. Epub 2022 Jan 19.
9
Racial-ethnic differences in health-related quality of life among adults and children with glomerular disease.患有肾小球疾病的成人和儿童在健康相关生活质量方面的种族差异。
Glomerular Dis. 2021 Aug;1(3):105-117. doi: 10.1159/000516832. Epub 2021 Jun 24.
10
Understanding the Link between Neighborhoods and Kidney Disease.理解邻里环境与肾脏疾病之间的联系。
Kidney360. 2020 Aug;1(8):845-854. doi: 10.34067/kid.0001202019. Epub 2020 Aug 27.