橄榄体脑桥小脑萎缩患者大脑中免疫反应性促甲状腺激素释放激素的浓度。

Concentrations of immunoreactive thyrotropin-releasing hormone in the brain of patients with olivoponto-cerebellar atrophy.

作者信息

Mitsuma T, Nogimori T, Adachi K, Mukoyama M, Ando K, Sobue I

出版信息

J Neurol Sci. 1985 Dec;71(2-3):369-75. doi: 10.1016/0022-510x(85)90075-9.

Abstract

The concentrations of immunoreactive thyrotropin-releasing hormone (ir-TRH) in the brain of patients with olivoponto-cerebellar atrophy (OPCA) were studied. Three patients with OPCA and 8 non-central nervous system degenerative diseases were subjects in this study. Ir-TRH concentration in the brain was measured by radioimmunoassay. Ir-TRH was present in all parts of the dissected brain tissues (hypothalamus, frontal lobe, cerebellar cortex, olivary n., dentate n. and caudate n.) of patients with OPCA and non-central nervous system degenerative diseases. Ir-TRH concentration in the brain of case 1 and 2 was lower in the cerebellar cortex and olivary n., in contrast, ir-TRH concentration in case 3 was higher in the dentate n. The regions and the severity of pathological changes were different in each case of OPCA and changes in ir-TRH concentration in the brain did not always correlate with the severity of pathological changes. These findings suggest that changes in ir-TRH concentration in the brain of patients with OPCA may differ in each case, and may play some pathophysiological role in OPCA.

摘要

对橄榄体脑桥小脑萎缩（OPCA）患者大脑中免疫反应性促甲状腺激素释放激素（ir-TRH）的浓度进行了研究。本研究以3例OPCA患者和8例非中枢神经系统退行性疾病患者为研究对象。采用放射免疫分析法测定大脑中的ir-TRH浓度。OPCA患者和非中枢神经系统退行性疾病患者的所有解剖脑组织部位（下丘脑、额叶、小脑皮质、橄榄核、齿状核和尾状核）均存在ir-TRH。病例1和病例2大脑中，小脑皮质和橄榄核中的ir-TRH浓度较低，相比之下，病例3齿状核中的ir-TRH浓度较高。OPCA的每个病例中，病变区域和严重程度各不相同，大脑中ir-TRH浓度的变化并不总是与病理变化的严重程度相关。这些发现表明，OPCA患者大脑中ir-TRH浓度的变化在每个病例中可能有所不同，并且可能在OPCA中发挥某些病理生理作用。