Infertility and IVF Unit, Rabin Medical Center, Helen Schneider Hospital for Women, Petach Tikva, 4941492, Israel.
School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
BMC Pregnancy Childbirth. 2024 Oct 5;24(1):651. doi: 10.1186/s12884-024-06814-3.
With the advancement in embryology and the introduction of time-lapse monitoring system, the embryologists' goal might be to find not only the embryo with the highest probability of live birth, but also the embryo with the highest probability to progress to a healthy full-term delivery. Thus, we aimed to investigate the association between morphokinetic time-lapse parameters and obstetrical and perinatal complications.
A cohort study reviewing fertility and delivery files of all singletone births from IVF patients whose embryos were cultured in a time-lapse monitoring system and had a single fresh embryo transfer at our center between 2013-2019. We conducted multiple comparisons between complicated and uncomplicated pregnancies of each perinatal complication, including: gestational diabetes mellitus (GDM); small for gestational age (SGA); pre-eclamptic toxemia (PET); preterm labor < 37 weeks of gestation (PTL); and third stage of labor complications. A comparison between pregnancies with and without a composite outcome of placental complications including GDM, SGA, PET and PTL was also conducted. Baseline characteristics, treatment and morphokinetic parameters in complicated and uncomplicated gestations were compared. Logistic regression analysis was utilized to adjust results for potential confounders.
One hundred seventy-six single embryo transfers resulted in 176 live births. Morphokinetic time-lapse parameters were similar between the groups, except for a shorter time to full blastulation in the SGA group (tB-tPNf = 75.5 ± 1.3 h vs. 79.5 ± 4.8 in the non-SGA group, p < 0.001), and shorter third cell cycle duration in the PET group (CC3 = 12.4 ± 1.1 h vs. 13.6 ± 2.9 in the non-PET group, p = 0.02). On multivariate regression analysis, none of the morphokinetic parameters were found to be significantly correlated with any of the perinatal complications.
Time-lapse morphokinetic parameters of the embryo transferred are not associated with adverse obstetric and perinatal outcomes.
随着胚胎学的进步和时差监测系统的引入，胚胎学家的目标可能不仅是找到活产概率最高的胚胎，而且是找到最有可能健康足月分娩的胚胎。因此，我们旨在研究时差形态动力学参数与产科和围产儿并发症之间的关系。
这是一项回顾性队列研究，分析了 2013 年至 2019 年在我们中心进行的体外受精患者的生育和分娩文件，这些患者的胚胎在时差监测系统中培养，并进行了单次新鲜胚胎移植。我们对每个围产儿并发症的复杂和简单妊娠进行了多次比较，包括：妊娠期糖尿病（GDM）；小于胎龄儿（SGA）；子痫前期；早产（PTL）；第三产程并发症。还比较了伴有或不伴有胎盘并发症（包括 GDM、SGA、PET 和 PTL）的复合结局的妊娠。比较了复杂和简单妊娠的基本特征、治疗和形态动力学参数。利用逻辑回归分析对潜在混杂因素进行调整。
176 个胚胎移植后 176 例活产。除了 SGA 组的完全囊胚形成时间较短（tB-tPNf=75.5±1.3 小时与非 SGA 组的 79.5±4.8 小时，p<0.001）和 PET 组的第三细胞周期持续时间较短（CC3=12.4±1.1 小时与非 PET 组的 13.6±2.9 小时，p=0.02）外，两组之间的时差形态动力学参数相似。多元回归分析显示，胚胎移植的时差形态动力学参数与任何围产儿并发症均无显著相关性。
移植胚胎的时差形态动力学参数与不良产科和围产儿结局无关。
