髓鞘少突胶质细胞糖蛋白抗体相关疾病患者与水通道蛋白 4 免疫球蛋白 G 阳性视神经脊髓炎谱系疾病患者的生活质量比较：一项韩国多中心研究。
Quality of life in patients with myelin oligodendrocyte glycoprotein antibody associated disease compared to patients with AQP4-IgG positive neuromyelitis optica spectrum disorders: A Korean multicenter study.
机构信息
Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea; Department of Neurology, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
出版信息
Mult Scler Relat Disord. 2024 Nov;91:105914. doi: 10.1016/j.msard.2024.105914. Epub 2024 Sep 30.
BACKGROUND
Little is known about the quality of life (QOL) of patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). We compared QOL and associated factors in patients with MOGAD and aquaporin4 IgG (AQP4-IgG) positive neuromyelitis optica spectrum disorder (NMOSD).
METHODS
This multicenter questionnaire study compared the QOL of 41 patients with MOGAD and 78 with AQP4-IgG positive NMOSD. Patients who were positive for AQP4-IgG or MOG antibodies were included. WHO Quality of Life Scale Brief Version was used to assess QOL in physical, psychological, social, and environmental domains. QOL, sleep quality, pain, fatigue, and depression were compared between the two groups. The factors associated with QOL in each group and the entire cohort were analyzed.
RESULTS
The proportion of patients with poor QOL was not significantly different between MOGAD (51.22 %) and AQP4-IgG positive NMOSD (58.97 %, p = 0.054). In the MOGAD group, the pain score (β=-1.032, p = 0.001) and depression score (β=-0.694, p = 0.007) were negatively associated with physical and psychological QOL, respectively. Sleep quality was negatively associated with physical (β=-1.506, p = 0.034) and psychological (β =-2.064, p = 0.033) QOL. When the entire cohort was analyzed, a positive MOG antibody was independently associated with worse psychological QOL (β=-8.998, p = 0.013) compared to positive AQP4-Ab after adjustment for sleep quality, depression, fatigue, and pain.
CONCLUSIONS
The overall QOL of the patients of MOGAD was comparable to that of AQP4-IgG positive NMOSD. Patients with MOGAD were experiencing sleep disorder, fatigue, and depression at similar degrees to those of patients with AQP4-IgG positive NMOSD. Further consideration of sleep quality and psychological QOL is required to improve QOL in patients with MOGAD.
背景
关于髓鞘少突胶质细胞糖蛋白抗体相关性疾病（MOGAD）患者的生活质量（QOL）知之甚少。我们比较了 MOGAD 患者和水通道蛋白 4 免疫球蛋白 G（AQP4-IgG）阳性视神经脊髓炎谱系疾病（NMOSD）患者的 QOL 及其相关因素。
方法
这项多中心问卷调查研究比较了 41 例 MOGAD 患者和 78 例 AQP4-IgG 阳性 NMOSD 患者的 QOL。纳入了 AQP4-IgG 或 MOG 抗体阳性的患者。采用世界卫生组织生活质量量表简表评估身体、心理、社会和环境领域的 QOL。比较两组患者的 QOL、睡眠质量、疼痛、疲劳和抑郁情况。分析了各组和整个队列中与 QOL 相关的因素。
结果
MOGAD 组（51.22%）和 AQP4-IgG 阳性 NMOSD 组（58.97%）的 QOL 较差患者比例无显著差异（p=0.054）。在 MOGAD 组中，疼痛评分（β=-1.032，p=0.001）和抑郁评分（β=-0.694，p=0.007）与身体和心理 QOL 分别呈负相关。睡眠质量与身体（β=-1.506，p=0.034）和心理（β=-2.064，p=0.033）QOL 呈负相关。当对整个队列进行分析时，与 AQP4-Ab 阳性相比，调整睡眠质量、抑郁、疲劳和疼痛后，阳性 MOG 抗体与更差的心理 QOL 独立相关（β=-8.998，p=0.013）。
结论
MOGAD 患者的整体 QOL 与 AQP4-IgG 阳性 NMOSD 患者相当。MOGAD 患者与 AQP4-IgG 阳性 NMOSD 患者一样存在睡眠障碍、疲劳和抑郁。需要进一步考虑睡眠质量和心理 QOL，以改善 MOGAD 患者的 QOL。
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