Sun Jieping, Zhang Mengzhe, Dang Jinghan, Niu Xiaoyu, Tao Qiuying, Kang Yimeng, Ma Longyao, Mei Bohui, Wei Yarui, Wang Weijian, Han Shaoqiang, Cheng Jingliang, Zhang Yong
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Henan Province, China.
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Henan Province, China.
J Psychiatr Res. 2024 Dec;180:39-46. doi: 10.1016/j.jpsychires.2024.09.051. Epub 2024 Oct 2.
The impact of tobacco smoking on global health persists and it is essential to understand the progression of addiction and the involvement of neurotransmitters.
This study assessed 47 participants with tobacco use disorder (TUD) categorized based on changes in Fagerström Test for Nicotine Dependence (FTND) scores over 6 years: progressive TUD (pTUD), regressive TUD (rTUD), and stable TUD (sTUD). Additionally, 35 healthy controls were included. Resting-state functional magnetic resonance imaging was used to evaluate brain regional homogeneity (ReHo) and correlations with neurotransmitter distributions using JuSpace.
Significant differences in ReHo were observed among pTUD, rTUD, sTUD, and controls. After strict Bonferroni correction, rTUD exhibited increased ReHo in the dorsolateral superior frontal gyrus compared to sTUD (p < 0.001) and controls (p < 0.001). Both pTUD (p < 0.001) and rTUD (p < 0.001) showed decreased ReHo in the superior temporal gyrus compared to sTUD. sTUD had increased ReHo in the supramarginal gyrus compared to all other groups (p < 0.001, p < 0.001, p = 0.002, separately). The strongest association, which survived rigorous Bonferroni correction, was between the ReHo changes in rTUD compared to sTUD and neurotransmitter distribution. This includes 5-hydroxytryptamine receptor 2A (p = 0.001), gamma-aminobutyric acid type A receptor (p < 0.001), norepinephrine transporter (p < 0.001), and N-Methyl-D-Aspartate (p = 0.002).
This study provides insights into how smoking behaviors correlate with alterations in brain activity and neurotransmitter function. By elucidating these neural links to tobacco use disorder progression, our findings contribute to a deeper understanding of smoking's neurological impact and potentially inform more targeted therapeutic strategies.
吸烟对全球健康的影响持续存在，了解成瘾的进展以及神经递质的参与至关重要。
本研究评估了47名烟草使用障碍（TUD）参与者，根据尼古丁依赖的Fagerström测试（FTND）分数在6年中的变化进行分类：进行性TUD（pTUD）、退行性TUD（rTUD）和稳定TUD（sTUD）。此外，纳入了35名健康对照者。静息态功能磁共振成像用于评估脑区同质性（ReHo），并使用JuSpace评估与神经递质分布的相关性。
在pTUD、rTUD、sTUD和对照者之间观察到ReHo存在显著差异。经过严格的Bonferroni校正后，与sTUD（p < 0.001）和对照者（p < 0.001）相比，rTUD在背外侧额上回的ReHo增加。与sTUD相比，pTUD（p < 0.001）和rTUD（p < 0.001）在颞上回的ReHo均降低。与所有其他组相比，sTUD在缘上回的ReHo增加（分别为p < 0.001、p < 0.001、p = 0.002）。在经过严格的Bonferroni校正后仍存在的最强关联是rTUD与sTUD相比的ReHo变化与神经递质分布之间的关联。这包括5-羟色胺受体2A（p = 0.001）、γ-氨基丁酸A型受体（p < 0.001）、去甲肾上腺素转运体（p < 0.001）和N-甲基-D-天冬氨酸（p = 0.002）。
本研究深入探讨了吸烟行为与脑活动和神经递质功能改变之间的关联。通过阐明这些与烟草使用障碍进展相关的神经联系，我们的研究结果有助于更深入地理解吸烟的神经学影响，并可能为更有针对性的治疗策略提供依据。
