Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Eur J Pharmacol. 2024 Dec 5;984:177038. doi: 10.1016/j.ejphar.2024.177038. Epub 2024 Oct 5.
Perioperative neurocognitive disorder (PND) is a common complication of surgical anesthesia, yet its precise etiology remains unclear. Neuroinflammation is a key feature of PND, influenced by both patient -related and surgical variables. The nuclear factor-κB (NF-κB) transcription factor family plays a critical role in regulating the body's immunological proinflammatory response, which is pivotal in the development of PND. Surgery and anesthesia trigger the activation of the NF-κB signaling pathway, leading to the initiation of inflammatory cascades, disruption of the blood-brain barrier, and neuronal injury. Immune cells and glial cells are central to these pathological processes in PND. Furthermore, this study explores the interactions between NF-κB and various signaling molecules, including Tlr4, P2X, α7-nAChR, ROS, HIF-1α, PI3K/Ak, MicroRNA, Circular RNA, and histone deacetylases, within the context of PND. Targeting NF-κB as a therapeutic approach for PND shows promise as a potential treatment strategy.
围手术期神经认知障碍（PND）是手术麻醉的常见并发症，但确切病因仍不清楚。神经炎症是 PND 的一个关键特征，受患者相关和手术变量的影响。核因子-κB（NF-κB）转录因子家族在调节机体免疫性促炎反应中发挥着关键作用，这对于 PND 的发生至关重要。手术和麻醉会触发 NF-κB 信号通路的激活，导致炎症级联反应的启动、血脑屏障的破坏和神经元损伤。免疫细胞和神经胶质细胞是 PND 中这些病理过程的核心。此外，本研究还探讨了 NF-κB 与各种信号分子（包括 Tlr4、P2X、α7-nAChR、ROS、HIF-1α、PI3K/Ak、miRNA、Circular RNA 和组蛋白去乙酰化酶）之间的相互作用，这些信号分子在 PND 中发挥作用。作为 PND 的治疗方法，靶向 NF-κB 显示出作为一种潜在治疗策略的前景。
