Fahrbach Susan E
Department of Biology, Wake Forest University, Winston-Salem, NC 27109, USA.
Curr Opin Insect Sci. 2024 Dec;66:101278. doi: 10.1016/j.cois.2024.101278. Epub 2024 Oct 5.
Structural plasticity is the hallmark of the protocerebral mushroom bodies of adult insects. This plasticity is especially well studied in social hymenopterans. In adult worker honey bees, phenomena such as increased neuropil volume, increased dendritic branching, and changes in the details of synaptic microcircuitry are associated with both the onset of foraging and the accumulation of foraging experience. Prior models of the drivers of these changes have focused on differences between the sensory environment of the hive and the world outside the hive, leading to enhanced excitatory (cholinergic) inputs to the intrinsic neurons of the mushroom bodies (Kenyon cells). This article proposes experimental and bioinformatics-based approaches for the exploration of a role for changes in the inhibitory (GABAergic) innervation of the mushroom bodies as a driver of sensitive periods for structural plasticity in the honey bee brain.
结构可塑性是成年昆虫原脑蘑菇体的标志。这种可塑性在社会性膜翅目昆虫中得到了特别深入的研究。在成年工蜂中，诸如神经纤维体积增加、树突分支增多以及突触微电路细节变化等现象，都与觅食行为的开始和觅食经验的积累有关。此前关于这些变化驱动因素的模型主要集中在蜂巢内与蜂巢外感觉环境的差异上，这导致对蘑菇体固有神经元（肯扬细胞）的兴奋性（胆碱能）输入增强。本文提出了基于实验和生物信息学的方法，以探索蘑菇体抑制性（γ-氨基丁酸能）神经支配的变化作为蜜蜂大脑结构可塑性敏感期驱动因素的作用。
