艰难梭菌毒素B抑制人类中性粒细胞迁移。

Clostridioides difficile toxin B suppresses human neutrophil migration.

作者信息

Kimura Yoshitaka, Hatayama Nami, Sato Yoshinori, Yoshino Yusuke

机构信息

Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Anaerobe. 2024 Dec;90:102916. doi: 10.1016/j.anaerobe.2024.102916. Epub 2024 Oct 5.

DOI:10.1016/j.anaerobe.2024.102916

PMID:39369979

Abstract

We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system.

摘要

我们研究了艰难梭菌感染（CDI）的主要毒力因子艰难梭菌毒素B（TcdB）对人中性粒细胞的影响。TcdB通过响应白细胞介素-8使F-肌动蛋白聚合极性丧失来抑制中性粒细胞迁移。TcdB通过使艰难梭菌避开宿主免疫系统来促进CDI。