Kimura Yoshitaka, Hatayama Nami, Sato Yoshinori, Yoshino Yusuke
Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan.
Department of Microbiology and Immunology, Teikyo University School of Medicine, Tokyo, Japan.
Anaerobe. 2024 Dec;90:102916. doi: 10.1016/j.anaerobe.2024.102916. Epub 2024 Oct 5.
We investigated the effects of Clostridioides difficile toxin B (TcdB), a major virulence factor in C. difficile infection (CDI), on human neutrophils. TcdB inhibits neutrophil migration via loss of polarity of F-actin polymerization in response to interleukin-8. TcdB facilitates CDI by allowing C. difficile to avert the host immune system.
我们研究了艰难梭菌感染（CDI）的主要毒力因子艰难梭菌毒素B（TcdB）对人中性粒细胞的影响。TcdB通过响应白细胞介素-8使F-肌动蛋白聚合极性丧失来抑制中性粒细胞迁移。TcdB通过使艰难梭菌避开宿主免疫系统来促进CDI。
