一项前瞻性队列研究：炎症性肠病患者患慢性呼吸道疾病的风险增加
Increased Risk of Chronic Respiratory Disease among Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study.
作者信息
Dan Lintao, Xie Ying, Fu Tian, Sun Yuhao, Chen Xuejie, Wang Xiaoyan, Wu Chenkai, Chen Jie, Li Xue
机构信息
Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China; Department of Big Data in Health Science School of Public Health, Center of Clinical Big Data and Analytics of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; The Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
出版信息
Am J Med. 2025 Jan;138(1):42-50.e5. doi: 10.1016/j.amjmed.2024.09.001. Epub 2024 Oct 5.
BACKGROUND
Cross-sectional evidence suggests a higher burden of chronic respiratory diseases in people with inflammatory bowel disease, but there is a lack of prospective evidence to clarify the direction of their associations. We aimed to investigate the association of inflammatory bowel disease with the risk of 2 major chronic respiratory diseases, chronic obstructive pulmonary disease, and asthma.
METHODS
We included 430,414 participants from UK Biobank and followed them from recruitment (2006-2010) to 2021. Chronic obstructive pulmonary disease and asthma cases were obtained from inpatient data and death register. Using Cox proportional hazards models, we estimated the multivariable-adjusted hazard ratios (HR) of developing chronic obstructive pulmonary disease and asthma in participants with inflammatory bowel disease compared with inflammatory bowel disease-free groups. We also investigated the association among Crohn's disease and ulcerative colitis with the risk of chronic obstructive pulmonary disease and asthma.
RESULTS
Over a median follow-up of 11.9 years, there were 11,196 incidents of chronic obstructive pulmonary disease and 9831 asthma cases. The adjusted HRs of developing chronic obstructive pulmonary disease (HR 1.54; 95% confidence interval [CI], 1.33-1.79) and asthma (HR 1.52; 95% CI, 1.29-1.79) were higher for those with inflammatory bowel disease when compared with inflammatory bowel disease-free participants. Participants with Crohn's disease and ulcerative colitis were also found to have a higher risk of chronic obstructive pulmonary disease (Crohn's disease: HR 1.71; 95% CI, 1.36-2.15; ulcerative colitis: HR 1.45; 95% CI, 1.20-1.75) and asthma (Crohn's disease: HR 1.73; 95% CI, 1.33-2.25; ulcerative colitis: HR 1.41; 95% CI, 1.15-1.73) when compared with those free of inflammatory bowel disease.
CONCLUSIONS
This study suggested that individuals with inflammatory bowel disease have a higher risk of developing chronic obstructive pulmonary disease and asthma, highlighting the importance of preventing chronic respiratory diseases among inflammatory bowel disease patients.
背景
横断面证据表明炎症性肠病患者的慢性呼吸道疾病负担更高，但缺乏前瞻性证据来阐明它们之间关联的方向。我们旨在研究炎症性肠病与两种主要慢性呼吸道疾病（慢性阻塞性肺疾病和哮喘）风险之间的关联。
方法
我们纳入了英国生物银行的430,414名参与者，并从招募（2006 - 2010年）开始对他们进行随访直至2021年。慢性阻塞性肺疾病和哮喘病例来自住院数据和死亡登记。使用Cox比例风险模型，我们估计了炎症性肠病患者与无炎症性肠病组相比发生慢性阻塞性肺疾病和哮喘的多变量调整风险比（HR）。我们还研究了克罗恩病和溃疡性结肠炎与慢性阻塞性肺疾病和哮喘风险之间的关联。
结果
在中位随访11.9年期间，有11,196例慢性阻塞性肺疾病事件和9,831例哮喘病例。与无炎症性肠病的参与者相比，炎症性肠病患者发生慢性阻塞性肺疾病（HR 1.54；95%置信区间[CI]，1.33 - 1.79）和哮喘（HR 1.52；95% CI，1.29 - 1.79）的调整后HR更高。还发现患有克罗恩病和溃疡性结肠炎的参与者发生慢性阻塞性肺疾病（克罗恩病：HR 1.71；95% CI，1.36 - 2.15；溃疡性结肠炎：HR 1.45；95% CI，1.20 - 1.75）和哮喘（克罗恩病：HR 1.73；95% CI，1.33 - 2.25；溃疡性结肠炎：HR 1.41；95% CI，1.15 - 1.73）的风险高于无炎症性肠病的参与者。
结论
这项研究表明炎症性肠病患者发生慢性阻塞性肺疾病和哮喘的风险更高，突出了在炎症性肠病患者中预防慢性呼吸道疾病的重要性。
Zotero 插件