Center for Cutaneous Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.
Transplant Cell Ther. 2024 Sep;30(9S):S513-S533. doi: 10.1016/j.jtct.2024.05.020.
Cutaneous chronic graft-versus-host disease (cGVHD) is associated with morbidity, mortality, and impaired quality of life after hematopoietic stem cell transplantation. The clinical features of cutaneous cGVHD are heterogeneous but can be broadly classified into nonsclerotic or sclerotic presentations. This review provides an overview of clinical presentation, diagnosis and differential diagnosis, grading, and treatment of cutaneous cGVHD. Particular attention is given to cutaneous cGVHD in skin of color, which can have unique features and is generally underrepresented in the literature leading to delays in diagnosis. Finally, an overview of long-term skin care for patients with cutaneous cGVHD is provided in order to support patients from a dermatologic perspective as they recover from cGVHD. Multidisciplinary care with frequent communication between transplant specialists and dermatologists is critical to effectively managing cutaneous cGVHD.
皮肤慢性移植物抗宿主病（cGVHD）与造血干细胞移植后发病率、死亡率和生活质量受损有关。皮肤 cGVHD 的临床特征具有异质性，但可广泛分为非硬化或硬化表现。本综述提供了皮肤 cGVHD 的临床表现、诊断和鉴别诊断、分级和治疗的概述。特别关注有色人种的皮肤 cGVHD，其具有独特的特征，在文献中普遍代表性不足，导致诊断延迟。最后，提供了皮肤 cGVHD 患者的长期皮肤护理概述，以便从皮肤科角度支持患者从 cGVHD 中康复。多学科护理，移植专家和皮肤科医生之间频繁沟通，对于有效管理皮肤 cGVHD 至关重要。
