Division of Brain Science, Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.
Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Kagoshima 890-8544, Japan.
Biomed Res. 2024;45(5):209-216. doi: 10.2220/biomedres.45.209.
Brain-derived neurotrophic factor (BDNF) plays an important role in mental stress. We have previously reported that 1,5-anhydro-D-fructose (1,5-AF) increases brain BDNF in vivo. The present randomized, controlled, double-blind study aimed to clinically evaluate the effects of 1,5-AF oral intake on mental stress in terms of three parameters: sleep, mood, and bowel issues. Healthy volunteers aged between 22 and 71 years (n = 24) were randomly assigned to receive 5.5 g of 1,5-AF or placebo orally, once daily for 4 weeks. Pre- and post-intervention, the subjects completed the Oguri-Shirakawa-Azumi Sleep Inventory, Middle-Aged and Aged Version (OSA-MA); Profile of Mood States, Second Edition (POMS2); and Constipation Assessment Scale (CAS) questionnaires. In the OSA-MA, both "sleepiness on rising" and "sleep length" were significantly improved after treatment with 1,5-AF compared with before treatment. Furthermore, in the POMS2, there was a clear tendency toward reduced "Anger-Hostility" in the 1,5-AF group after treatment, and in the CAS, there was a clear tendency toward reduced "diarrhea or liquid stool" in the 1,5-AF group after treatment. Together, our findings indicate that 1,5-AF has some effects on reducing post-intervention mental stress levels.
脑源性神经营养因子（BDNF）在精神应激中发挥重要作用。我们之前的研究报道过 1,5-脱水-D-果糖（1,5-AF）可以增加体内脑源性神经营养因子。本项随机、对照、双盲研究旨在从睡眠、情绪和肠道问题三个参数方面，临床评估 1,5-AF 口服摄入对精神应激的影响。年龄在 22 至 71 岁的健康志愿者（n = 24）被随机分为两组，分别每天口服 5.5 g 1,5-AF 或安慰剂，持续 4 周。在干预前后，受试者完成了小泉等修订的睡眠问卷（Oguri-Shirakawa-Azumi Sleep Inventory，OSA-MA）、心境状态问卷第二版（Profile of Mood States，POMS2）和便秘评估量表（Constipation Assessment Scale，CAS）。在 OSA-MA 中，与治疗前相比，1,5-AF 治疗后“起床时困倦”和“睡眠时间”均显著改善。此外，在 POMS2 中，治疗后 1,5-AF 组“愤怒敌意”有明显降低的趋势，在 CAS 中，治疗后 1,5-AF 组“腹泻或稀便”也有明显减少的趋势。综上所述，我们的研究结果表明，1,5-AF 对降低干预后精神应激水平有一定作用。
