Lundgaard Maja H, Sinding Marianne M, Sørensen Anne N, Torp Nanna M U, Handberg Aase, Andersen Stig, Andersen Stine L
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Clin Endocrinol (Oxf). 2025 Mar;102(3):306-314. doi: 10.1111/cen.15145. Epub 2024 Oct 6.
A link between maternal thyroid function and the placental biomarkers, soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF), has been brought forward. This study aimed to describe their association in early pregnancy.
Retrospective cohort study.
Eight hundred and fifty-eight pregnant women from the North Denmark Region, 2013, with blood samples drawn in early pregnancy.
Thyroid-stimulating hormone (TSH), free thyroxine (fT4), thyroid-peroxidase antibodies (TPO-Ab), thyroglobulin antibodies (Tg-Ab) (ADVIA Centaur XPT, Siemens Healthineers), sFlt-1 and PlGF (Kryptor Compact, ThermoFisher Scientific) were measured. The association between maternal TSH and fT4 and percentile (pc) levels of sFlt-1 and PlGF (< 25th pc, 25-75th pc, > 75th pc) was evaluated using regression analysis and reported as adjusted beta coefficient (aβ). The frequency of maternal thyroid autoantibodies (TPO-Ab > 60 U/mL or Tg-Ab > 33 U/mL) by pc levels of sFlt-1 and PlGF was compared using chi-squared test.
Higher levels (> 75th pc) of sFlt-1 associated with lower TSH (aβ 0.62, 95% CI: 0.51-0.76) and higher fT4 (aβ 1.03, 95% CI: 1.01-1.05). Higher levels of PlGF associated with lower TSH (aβ 0.82, 95% CI: 0.69-0.98), but not with levels of fT4 (aβ 1.00, 95% CI: 0.97-1.02). No association with maternal thyroid autoantibodies was found (TPO-Ab: sFlt-1: p-value 0.5 and PlGF: p-value 0.1; Tg-Ab: sFlt-1: p-value 0.7 and PlGF: p-value 0.1).
In a large cohort of Danish pregnant women, higher levels of sFlt-1 and PlGF associated with maternal thyroid function in early pregnancy, while there was no association with maternal thyroid autoantibodies.
已提出母体甲状腺功能与胎盘生物标志物可溶性fms样酪氨酸激酶-1（sFlt-1）和胎盘生长因子（PlGF）之间的联系。本研究旨在描述它们在妊娠早期的关联。
回顾性队列研究。
2013年来自丹麦北部地区的858名孕妇，在妊娠早期采集了血样。
检测促甲状腺激素（TSH）、游离甲状腺素（fT4）、甲状腺过氧化物酶抗体（TPO-Ab）、甲状腺球蛋白抗体（Tg-Ab）（西门子医疗的ADVIA Centaur XPT）、sFlt-1和PlGF（赛默飞世尔科技的Kryptor Compact）。使用回归分析评估母体TSH和fT4与sFlt-1和PlGF百分位数（pc）水平（<25th pc、25 - 75th pc、>75th pc）之间的关联，并报告为校正β系数（aβ）。使用卡方检验比较sFlt-1和PlGF的pc水平下母体甲状腺自身抗体（TPO-Ab > 60 U/mL或Tg-Ab > 33 U/mL）的频率。
较高水平（>75th pc）的sFlt-1与较低的TSH（aβ 0.62，95%CI：0.51 - 0.76）和较高的fT4（aβ 1.03，95%CI：1.01 - 1.05）相关。较高水平的PlGF与较低的TSH（aβ 0.82，95%CI：0.69 - 0.98）相关，但与fT4水平无关（aβ 1.00，95%CI：0.97 - 1.02）。未发现与母体甲状腺自身抗体有关联（TPO-Ab：sFlt-1：p值0.5，PlGF：p值0.1；Tg-Ab：sFlt-1：p值0.7，PlGF：p值0.1）。
在一大群丹麦孕妇中，较高水平的sFlt-1和PlGF与妊娠早期的母体甲状腺功能相关，而与母体甲状腺自身抗体无关联。
