Department of Medical Imaging Center, The First Affiliated Hospital, Department of Chemistry, Jinan University, Guangzhou 510630, China.
The Shunde Affiliated Hospital, Jinan University, Foshan 528300, China.
ACS Nano. 2024 Oct 15;18(41):27853-27868. doi: 10.1021/acsnano.4c00516. Epub 2024 Oct 7.
Ultrahigh field magnetic resonance imaging (UHF-MRI) (≥7 T) can dramatically boost image resolution and signal-to-noise ratio, which have distinct advantages in multifunctional imaging. However, their research and application are currently limited by the absence of high-field contrast agents (CAs) and the low sensitivity and accuracy of T1/T2 single-modality CAs. Therefore, the development of T1-T2 dual-mode CAs that respond to UHF-MRI and nanoformulations with therapeutic sensitization can bring ideas for the integrated application of precise and synchronous tumor theranostics. Herein, we present a biomimetic mineralization strategy for synthesizing holmium/manganese oxide-bovine serum albumin-photosensitizer chlorin e6 nanohybrids. The hybrid nanoparticles exhibited better tumor accumulation, a suitable time imaging window, and excellent pH-response T1-T2 dual-mode UHF-MRI performance. The antitumor effect comes from the amelioration of the hypoxic tumor microenvironment to promote the synergistic effect of photodynamic therapy and radiotherapy, along with negligible acute toxicity. Undoubtedly, this work not only provides a different perspective for developing multifunctional nanotherapeutics but also promotes the potential clinical exploitation and translation of UHF CAs.
超高场磁共振成像（UHF-MRI）（≥7T）可以显著提高图像分辨率和信噪比，在多功能成像中具有明显优势。然而，由于缺乏高场对比度剂（CA）以及 T1/T2 单模态 CA 的灵敏度和准确性较低，其研究和应用目前受到限制。因此，开发对 UHF-MRI 有响应的 T1-T2 双模态 CA 和具有治疗敏化作用的纳米制剂，可以为精确和同步的肿瘤治疗提供思路。在此，我们提出了一种仿生矿化策略，用于合成钬/锰氧化物-牛血清白蛋白-光敏剂氯吡啉 e6 纳米杂化物。该杂化纳米粒子表现出更好的肿瘤积累、合适的时间成像窗口以及优异的 pH 响应 T1-T2 双模态 UHF-MRI 性能。抗肿瘤作用源于改善缺氧肿瘤微环境以促进光动力治疗和放射治疗的协同作用，同时急性毒性可忽略不计。毫无疑问，这项工作不仅为开发多功能纳米治疗药物提供了新的视角，也促进了 UHF CA 的潜在临床开发和转化。
