College of Agroforestry and Health, The Open University of Sichuan, Chengdu, China.
Rural Education and Industrial Revitalization Research Center, The Open University of Sichuan, Chengdu, China.
Prim Health Care Res Dev. 2024 Oct 7;25:e41. doi: 10.1017/S1463423624000331.
High-risk Human Papillomavirus (HPV) infections are a leading cause of cervical diseases among Han Chinese women of reproductive age. Despite studies like Mai . (2021) addressing HPV prevalence in Southern China, awareness remains low, especially in Southwest China. Our study addresses this gap.
This hospital-based, retrospective study analyzes the prevalence of high-risk HPV and its association with cervical intraepithelial neoplasia (CIN) among Han Chinese women of reproductive age in Southwest China.
Data were collected from 724 women undergoing routine health exams from December 2022 to April 2023. A total of 102 women with high-risk HPV infections were identified. A survey assessed HPV awareness, CIN incidence, and socio-demographic factors influencing awareness.
Of the 724 women, 102 (14.1%) were diagnosed with high-risk HPV, with HPV-16 being the most common subtype (22.5%). Awareness was significantly lower among unmarried women (OR: 6.632, = 0.047), those with high school education or less (OR: 20.571, = 0.003), and rural residents (OR: 19.483, = 0.020). HPV-16 was detected in 54.55% of women with high-grade CIN.
There is an urgent need for targeted education and HPV vaccination in Southwest China, particularly for women with lower education, rural residents, and older individuals. Subtype-specific strategies are essential for preventing and managing CIN.
高危型人乳头瘤病毒（HPV）感染是导致中国汉族育龄妇女宫颈疾病的主要原因。尽管有像 Mai （2021）这样的研究针对中国南方的 HPV 流行情况进行了探讨，但人们的认识仍然很低，尤其是在中国西南部。本研究旨在填补这一空白。
本基于医院的回顾性研究分析了中国西南部汉族育龄妇女高危型 HPV 的流行情况及其与宫颈上皮内瘤变（CIN）的关系。
本研究于 2022 年 12 月至 2023 年 4 月期间收集了 724 名接受常规健康检查的女性的数据。共发现 102 名患有高危型 HPV 感染的女性。一项调查评估了 HPV 认知、CIN 发病率以及影响认知的社会人口学因素。
在 724 名女性中，有 102 名（14.1%）被诊断为高危型 HPV 感染，其中 HPV-16 是最常见的亚型（22.5%）。未结婚的女性（OR：6.632， = 0.047）、高中及以下学历的女性（OR：20.571， = 0.003）和农村居民（OR：19.483， = 0.020）的 HPV 认知率明显较低。在高级别 CIN 患者中，HPV-16 的检出率为 54.55%。
中国西南部迫切需要针对特定人群进行教育和 HPV 疫苗接种，特别是针对教育程度较低、农村居民和年龄较大的女性。针对特定亚型的策略对于预防和管理 CIN 至关重要。
