全身性妥卡尼、利多卡因和布比卡因对大鼠痛觉感受的影响。
The effect of systemic tocainide, lidocaine and bupivacaine on nociception in the rat.
作者信息
Wiesenfeld-Hallin Zsuzsanna, Lindblom Ulf
机构信息
Department of Clinical Neurophysiology, Huddinge University Hospital, S-141 86 Huddinge, and Department of Neurology, Karolinska Hospital, S-104 01 StockholmSweden.
出版信息
Pain. 1985 Dec;23(4):357-360. doi: 10.1016/0304-3959(85)90005-3.
PMID:3937115
Abstract
The analgesic properties of systemically administered tocainide, a primary amine congener of lidocaine with a longer duration of action, were examined in rats. Significant antinociception, as assayed on the hot-plate test, was observed after i.p. tocainide at doses below toxic levels. No antinociception was seen with non-toxic doses of lidocaine or bupivacaine.
摘要
在大鼠中研究了全身给药的妥卡尼（利多卡因的一种伯胺同系物，作用持续时间更长）的镇痛特性。腹腔注射低于中毒剂量的妥卡尼后，在热板试验中观察到显著的抗伤害感受作用。无毒剂量的利多卡因或布比卡因未观察到抗伤害感受作用。
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