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High frequency of clozapine-associated myocarditis and troponin elevation: Need for slower titration prospective studies.

作者信息

Kikuchi Yuki, Onodera Bunichiro, Komatsu Hiroshi, Tomita Hiroaki

机构信息

Psychiatrist, Department of Psychiatry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan; Department of Psychiatry, Kodama Hospital, Ishinomaki, Miyagi, Japan, ORCID: https://orcid.org/0009-0004-9354-3457.

Lecturer, Department of Psychiatry, Tohoku University Hospital, Sendai, Miyagi, Japan, ORCID: https://orcid.org/0000-0002-7602-0281.

出版信息

Ment Health Clin. 2024 Oct 1;14(5):302-303. doi: 10.9740/mhc.2024.10.302. eCollection 2024 Oct.

DOI:10.9740/mhc.2024.10.302
PMID:39371482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11451902/
Abstract
摘要

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1
High frequency of clozapine-associated myocarditis and troponin elevation: Need for slower titration prospective studies.氯氮平相关心肌炎和肌钙蛋白升高的高发生率:需要进行滴定速度较慢的前瞻性研究。
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2
Can Slow Personalized Titration Using C-Reactive Protein Monitoring Decrease the High Rates and Mortality of Clozapine-Associated Myocarditis Seen in Some Countries? A Call for Research.可否利用 C 反应蛋白监测进行缓慢个体化滴定以降低某些国家中氯氮平相关性心肌炎的高发生率和死亡率?呼吁开展相关研究。
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本文引用的文献

1
Evaluation of major adverse events of clozapine based on accordance to an international titration guideline.根据国际滴定指南评估氯氮平的主要不良事件。
Ment Health Clin. 2024 Jun 3;14(3):204-211. doi: 10.9740/mhc.2024.06.204. eCollection 2024 Jun.
2
Reply to "Obesity as a potential confounder of clozapine-induced myocarditis in the Hunter Region of Australia".
Schizophr Res. 2024 May;267:191-192. doi: 10.1016/j.schres.2024.03.005. Epub 2024 Apr 1.
3
Obesity as a potential confounder of clozapine-induced myocarditis in the Hunter region of Australia.
Schizophr Res. 2024 May;267:42-43. doi: 10.1016/j.schres.2024.03.004. Epub 2024 Mar 21.
4
High rates of myocarditis with clozapine in the Hunter region of Australia.澳大利亚亨特地区氯氮平导致心肌炎的发生率较高。
Schizophr Res. 2024 Feb;264:543-548. doi: 10.1016/j.schres.2024.01.030. Epub 2024 Feb 8.
5
Slower clozapine titration than the official Japanese protocol led to fewer inflammatory adverse effects: A retrospective chart review of seven hospitals.较日版方案更缓慢的氯氮平滴定导致更少的炎症不良反应:七家医院的回顾性图表分析。
Schizophr Res. 2024 Jun;268:98-106. doi: 10.1016/j.schres.2023.06.003. Epub 2023 Jun 16.