Georgakopoulou Vasiliki E, Dodos Konstantinos, Tarantinos Kyriakos
Department of Pathophysiology/Pulmonology, Laiko General Hospital, Athens, GRC.
Department of Respiratory Medicine, General Oncological Hospital of Kifissia "Agioi Anargyroi'', Athens, GRC.
Cureus. 2024 Sep 4;16(9):e68614. doi: 10.7759/cureus.68614. eCollection 2024 Sep.
The re-emergence of monkeypox as a significant global health concern has highlighted the need to reassess its clinical presentation, particularly its impact on pulmonary health. Traditionally associated with dermatological symptoms, recent outbreaks in non-endemic regions have underscored the virus's potential for widespread transmission and respiratory complications. Emerging evidence indicates that monkeypox infection can lead to respiratory symptoms such as cough, sore throat, and, in severe cases, pneumonia and acute respiratory distress syndrome (ARDS). The virus's capacity for respiratory transmission, coupled with the potential for coinfection with other respiratory pathogens, poses significant challenges for clinical management. Understanding the pathophysiology of monkeypox's impact on the lungs, which may involve direct viral invasion and immune-mediated damage, is critical for developing effective public health strategies. As monkeypox continues to spread, recognizing and addressing its respiratory complications will be essential in mitigating severe outcomes, particularly in vulnerable populations with pre-existing pulmonary conditions.
猴痘再度成为全球重大公共卫生问题，凸显了重新评估其临床表现的必要性，尤其是其对肺部健康的影响。猴痘传统上与皮肤病症状相关，但近期在非流行地区的疫情凸显了该病毒广泛传播和引发呼吸道并发症的可能性。新出现的证据表明，猴痘感染可导致咳嗽、喉咙痛等呼吸道症状，严重时可引发肺炎和急性呼吸窘迫综合征（ARDS）。该病毒的呼吸道传播能力，以及与其他呼吸道病原体合并感染的可能性，给临床管理带来了重大挑战。了解猴痘对肺部影响的病理生理学，这可能涉及病毒直接入侵和免疫介导的损伤，对于制定有效的公共卫生策略至关重要。随着猴痘持续传播，识别和应对其呼吸道并发症对于减轻严重后果至关重要，尤其是在已有肺部疾病的脆弱人群中。
