Singh Mayank, Shobhane Hema, Tiwari Kapil, Agarwal Shristy
Pathology, Maharani Laxmi Bai Medical College, Jhansi, IND.
Obstetrics and Gynecology, Maharani Laxmi Bai Medical College, Jhansi, IND.
Cureus. 2024 Sep 5;16(9):e68696. doi: 10.7759/cureus.68696. eCollection 2024 Sep.
Vitamin D deficiency during pregnancy can have severe effects on both the mother and the newborn child. The main aim of this study was to assess the impact of maternal vitamin D levels on the birth weight of the newborn by analysing the vitamin D levels in pregnant women at full term and their newborn.
The cross-sectional, hospital-based study was conducted with 150 consecutive women in labour presenting with a singleton term pregnancy at a large tertiary centre in the Bundelkhand region, India. Maternal and infant blood samples were obtained at the time of delivery. Umbilical cord blood was collected from infants, while maternal venous blood was drawn simultaneously. All relevant data were gathered, including the assessment of 25-hydroxy vitamin D3 levels in both mother and infant. The birth weight of the infant was measured, and statistical analysis was performed to find an association between maternal vitamin D level to birth weight and vitamin D level of the infant.
Most pregnant women had low vitamin D levels in this study. The results revealed a significant positive correlation between maternal serum vitamin D levels and infant birth weight (p < 0.001), suggesting that lower maternal vitamin D levels were associated with low birth weight in infants. Additionally, infant serum vitamin D levels showed a positive correlation with maternal vitamin D levels (p < 0.001), indicating that higher maternal vitamin D levels tend to have infants with higher vitamin D levels at birth.
These findings suggest a potential correlation of maternal vitamin D status to birth weight and vitamin D level of newborns, and further research is needed to confirm and better understand this relationship. Additionally, other factors such as maternal nutrition, genetics, lifestyle factors, and environmental influences may contribute to birth weight outcomes.
孕期维生素D缺乏会对母亲和新生儿都产生严重影响。本研究的主要目的是通过分析足月孕妇及其新生儿的维生素D水平，评估母亲维生素D水平对新生儿出生体重的影响。
这项基于医院的横断面研究在印度本德尔汗德地区一家大型三级中心，对150例连续单胎足月分娩的孕妇进行。在分娩时采集母婴血样。从婴儿处采集脐带血，同时抽取母亲静脉血。收集所有相关数据，包括母婴25-羟维生素D3水平的评估。测量婴儿出生体重，并进行统计分析以找出母亲维生素D水平与出生体重以及婴儿维生素D水平之间的关联。
本研究中大多数孕妇维生素D水平较低。结果显示母亲血清维生素D水平与婴儿出生体重之间存在显著正相关（p < 0.001），表明母亲维生素D水平较低与婴儿低出生体重有关。此外，婴儿血清维生素D水平与母亲维生素D水平呈正相关（p < 0.001），表明母亲维生素D水平较高的婴儿出生时维生素D水平往往也较高。
这些发现表明母亲维生素D状态与新生儿出生体重和维生素D水平之间可能存在关联，需要进一步研究来证实并更好地理解这种关系。此外，其他因素如母亲营养、遗传、生活方式因素和环境影响可能对出生体重结果有影响。
