Singh Chandra Veer, Jain Shraddha
Otolaryngology - Head and Neck Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2024 Sep 4;16(9):e68646. doi: 10.7759/cureus.68646. eCollection 2024 Sep.
Sensorineural hearing loss (SNHL) is a common form of hearing impairment characterized by damage to the inner ear or auditory nerve, resulting in significant communication difficulties and reduced quality of life. Current treatment options, including hearing aids, cochlear implants, and corticosteroids, primarily focus on symptom management and do not address the underlying pathophysiological damage. Platelet-rich plasma (PRP), an autologous concentrate rich in platelets and growth factors, has emerged as a potential regenerative therapy due to its ability to promote tissue repair and cellular regeneration. This review provides a comprehensive overview of the role of PRP in the management of SNHL, examining the current evidence from preclinical and clinical studies. We discuss the mechanisms through which PRP may promote auditory tissue regeneration and repair, analyze its efficacy and safety profile, and explore innovative approaches and future directions in its application for SNHL. Despite promising preliminary findings, further research is needed to optimize PRP protocols, establish standardized treatment guidelines, and conduct large-scale randomized controlled trials to validate efficacy. This review aims to highlight the potential of PRP as a novel therapeutic strategy in treating SNHL and its possible integration into current clinical practices, offering new hope for patients with this debilitating condition.
感音神经性听力损失（SNHL）是一种常见的听力障碍形式，其特征是内耳或听神经受损，导致严重的沟通困难和生活质量下降。目前的治疗选择，包括助听器、人工耳蜗和皮质类固醇，主要侧重于症状管理，并未解决潜在的病理生理损伤。富含血小板血浆（PRP）是一种富含血小板和生长因子的自体浓缩物，由于其促进组织修复和细胞再生的能力，已成为一种潜在的再生疗法。本综述全面概述了PRP在SNHL治疗中的作用，审视了临床前和临床研究的现有证据。我们讨论了PRP促进听觉组织再生和修复的机制，分析了其疗效和安全性概况，并探索了其在SNHL应用中的创新方法和未来方向。尽管初步研究结果令人鼓舞，但仍需要进一步研究以优化PRP方案、制定标准化治疗指南并开展大规模随机对照试验以验证疗效。本综述旨在强调PRP作为治疗SNHL的新型治疗策略的潜力及其可能融入当前临床实践的情况，为患有这种使人衰弱疾病的患者带来新的希望。
