Department of Reproductive Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Front Endocrinol (Lausanne). 2024 Sep 20;15:1427922. doi: 10.3389/fendo.2024.1427922. eCollection 2024.
Preimplantation genetic testing (PGT) allows for the evaluation of embryo genetic information prior to implantation, enabling the selection of normal embryos for transfer and ultimately leading to better pregnancy outcomes. In this study, we explored factors that influence clinical outcomes of patients undergoing PGT. The effects of blastocyst grading and biopsy dates on clinical outcomes were also analyzed.
The clinical data and pregnancy outcomes of 428 PGT cycles performed in the Reproductive Medicine Department of the Northern Theater General Hospital between January 2017 and December 2022 were retrospectively analyzed. Multifactorial logistic regression analysis and nomograms were used to determine factors influencing pregnancy outcomes. The impact of D5 blastocysts (290 cycles) and D6 blastocysts (138 cycles) with different quality levels on clinical outcomes was also compared.
Multifactorial logistic regression analysis showed that age, BMI, endometrial thickness, and embryo quality of women affected PGT clinical outcomes. Women aged <40 years or with a body mass index (BMI) >18.5 and endometrial thickness>1.0 cm had a significantly higher pregnancy success rate. Compared to that of D6 blastocyst biopsy, D5 blastocyst biopsy was associated with a higher pregnancy success rate but a similar live birth rate. No significant differences were observed in the pregnancy and live birth rates of D5 and D6 high-quality blastocysts.
To achieve better pregnancy outcomes after PGT, considering blastocyst grading and biopsy dates when transferring embryos is essential for improving pregnancy outcomes. Furthermore, patients should adjust their BMI, endometrial receptivity, and endometrial thickness and pattern.
胚胎植入前遗传学检测（PGT）允许在胚胎植入前评估胚胎的遗传信息，从而选择正常胚胎进行移植，最终导致更好的妊娠结局。在这项研究中，我们探讨了影响接受 PGT 的患者临床结局的因素。还分析了囊胚分级和活检日期对临床结局的影响。
回顾性分析 2017 年 1 月至 2022 年 12 月期间在北部战区总医院生殖医学科进行的 428 个 PGT 周期的临床数据和妊娠结局。采用多因素逻辑回归分析和列线图确定影响妊娠结局的因素。还比较了不同质量水平的 D5 囊胚（290 个周期）和 D6 囊胚（138 个周期）对临床结局的影响。
多因素逻辑回归分析表明，女性的年龄、BMI、子宫内膜厚度和胚胎质量影响 PGT 的临床结局。年龄<40 岁或 BMI>18.5 和子宫内膜厚度>1.0cm 的女性妊娠成功率显著更高。与 D6 囊胚活检相比，D5 囊胚活检与更高的妊娠成功率相关，但活产率相似。D5 和 D6 高质量囊胚的妊娠率和活产率无显著差异。
为了在 PGT 后获得更好的妊娠结局，在转移胚胎时考虑囊胚分级和活检日期对于改善妊娠结局至关重要。此外，患者应调整 BMI、子宫内膜容受性和子宫内膜厚度和模式。
