Department of Pediatrics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Department of Pediatrics, Children's Digital Health and Data Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Front Immunol. 2024 Sep 20;15:1443784. doi: 10.3389/fimmu.2024.1443784. eCollection 2024.
PIM1, the proviral integration site for Moloney murine leukemia virus, is a member of the serine/threonine protein kinase family. It is involved in many biological events, such as cell survival, cell cycle progression, cell proliferation, and cell migration, and has been widely studied in malignant diseases. However, recent studies have shown that PIM1 plays a prominent role in immunoinflammatory diseases, including autoimmune uveitis, inflammatory bowel disease, asthma, and rheumatoid arthritis. PIM1 can function in inflammatory signal transduction by phosphorylating multiple inflammatory protein substrates and mediating macrophage activation and T lymphocyte cell specification, thus participating in the development of multiple immunoinflammatory diseases. Moreover, the inhibition of PIM1 has been demonstrated to ameliorate certain immunoinflammatory disorders. Based on these studies, we suggest PIM1 as a potential therapeutic target for immunoinflammatory diseases and a valid candidate for future research. Herein, for the first time, we provide a detailed review that focuses on the roles of PIM1 in the pathogenesis of immunoinflammatory diseases.
PIM1，莫洛尼鼠白血病病毒的前病毒整合位点，是丝氨酸/苏氨酸蛋白激酶家族的一员。它参与许多生物学事件，如细胞存活、细胞周期进程、细胞增殖和细胞迁移，并在恶性疾病中得到了广泛研究。然而，最近的研究表明，PIM1 在免疫炎症性疾病中发挥着突出的作用，包括自身免疫性葡萄膜炎、炎症性肠病、哮喘和类风湿性关节炎。PIM1 可以通过磷酸化多种炎症蛋白底物和介导巨噬细胞激活和 T 淋巴细胞细胞特异性来发挥炎症信号转导作用，从而参与多种免疫炎症性疾病的发生。此外，抑制 PIM1 已被证明可以改善某些免疫炎症性疾病。基于这些研究，我们提出 PIM1 作为免疫炎症性疾病的潜在治疗靶点和未来研究的有效候选物。在此，我们首次提供了详细的综述，重点介绍了 PIM1 在免疫炎症性疾病发病机制中的作用。
