Ouhaddach Meryem, Zahlane Mouna, Essaadouni Lamiaâ
Service de Médecine Interne, Hôpital Arrazi CHU Mohamed VI, Marrakech, Maroc.
Pan Afr Med J. 2024 Sep 9;49:9. doi: 10.11604/pamj.2024.49.9.31779. eCollection 2024.
The emergence of severe acute respiratory syndrome coronavirus 2 has made it crucial to develop safe vaccines. Three main types of vaccines are currently available. Although they have proven to be very secure, they have caused various adverse effects. We here report a rare case of livedo reticularis following the administration of COVID-19 vaccine in a 54-year-old woman. It occurred 24 hours after vaccination, accompanied by respiratory, digestive, and neurological disorders and deterioration in general condition. Examinations revealed skin lesions compatible with livedo reticularis, mild inflammatory syndrome and hypercholesterolemia. Imaging showed no abnormalities. Immunological tests were positive for lupus anticoagulant. The patient received symptomatic treatment, with improvement in neurological and joint symptoms and a slight regression of skin rashes. After three months, the lupus anticoagulant test remained positive, confirming post-vaccination antiphospholipid syndrome (APS). The association of livedo reticularis with COVID-19 vaccine should not be underestimated and its degree of severity remains to be determined. More data and cases need to be collected for a more in-depth and detailed analysis.
严重急性呼吸综合征冠状病毒2的出现使得研发安全的疫苗至关重要。目前有三种主要类型的疫苗。尽管已证明它们非常安全，但仍引发了各种不良反应。我们在此报告一例54岁女性接种新冠疫苗后出现网状青斑的罕见病例。它在接种疫苗24小时后出现，伴有呼吸、消化和神经紊乱以及全身状况恶化。检查发现皮肤病变符合网状青斑、轻度炎症综合征和高胆固醇血症。影像学检查未发现异常。免疫测试狼疮抗凝物呈阳性。患者接受了对症治疗，神经和关节症状有所改善，皮疹略有消退。三个月后，狼疮抗凝物检测仍为阳性，证实为接种疫苗后抗磷脂综合征（APS）。网状青斑与新冠疫苗的关联不应被低估，其严重程度仍有待确定。需要收集更多数据和病例进行更深入、详细的分析。
