Mojica Elizabeth A, Petcu Kathleen A, Kültz Dietmar
Department of Animal Sciences and Genome Center, University of California-Davis, Davis, CA 95616, United States.
Environ Epigenet. 2024 Sep 2;10(1):dvae013. doi: 10.1093/eep/dvae013. eCollection 2024.
This study sheds new light on the timescale through which histone post-translational modifications (PTMs) respond to environmental stimuli, demonstrating that the histone PTM response does not necessarily precede the proteomic response or acclimation. After a variety of salinity treatments were administered to Mozambique tilapia () throughout their lifetimes, we quantified 343 histone PTMs in the gills of each fish. We show here that histone PTMs differ dramatically between fish exposed to distinct environmental conditions for 18 months, and that the majority of these histone PTM alterations persist for at least 4 weeks, irrespective of further salinity changes. However, histone PTMs respond minimally to 4-week-long periods of salinity acclimation during adulthood. The results of this study altogether signify that patterns of histone PTMs in individuals reflect their prolonged exposure to environmental conditions.
这项研究揭示了组蛋白翻译后修饰（PTM）对环境刺激作出反应的时间尺度，表明组蛋白PTM反应不一定先于蛋白质组反应或适应性变化。在莫桑比克罗非鱼（）的整个生命周期中进行了各种盐度处理后，我们对每条鱼鳃中的343种组蛋白PTM进行了定量。我们在此表明，暴露于不同环境条件18个月的鱼之间，组蛋白PTM存在显著差异，并且这些组蛋白PTM变化中的大多数至少持续4周，而与盐度的进一步变化无关。然而，成年期组蛋白PTM对为期4周的盐度适应反应极小。这项研究的结果共同表明，个体中组蛋白PTM的模式反映了它们长期暴露于环境条件的情况。
