Zhaffal Mokhamad, Tariq Shazia, Salame Anastasia
Obstetrics and Gynecology Department Kanad Hospital, Al Ain, UAE.
Reproductive Endocrinology and Infertility Fakih Medical Center, Al Ain, UAE.
Case Rep Oncol Med. 2024 Sep 27;2024:2259872. doi: 10.1155/2024/2259872. eCollection 2024.
Uterine leiomyomas are a frequent finding in women of reproductive age. However, rare, unusual growth patterns exist, such as atypical, cellular, mitotically active, myxoid, and epithelioid leiomyomas, and present a major concern as they mimic highly malignant uterine tumors such as uterine leiomyosarcomas. An example of such cases is the epithelial type leiomyoma which is the subject of our report in a 35-year-old female. A 35-year-old, nulliparous lady presented with abnormal uterine bleeding to the emergency department. Workup revealed a suspicious uterine mass that was extending from the intramural part of the fundus down the cervical os. The patient was managed by open myomectomy without complications. The final pathology report revealed an extremely rare benign epithelial type leiomyoma, no malignancy, areas with minimal atypia and low mitotic activity (< 5/10 high power fields), and areas of focal necroses (possibly ischemic type) were seen. No coagulative tumor necrosis was noted. Uterine leiomyomas are a common pathology of the uterus that can be confused with malignant tumors, especially in the setting of unusual growth patterns such as the epitheloid leiomyomas. Definitive management involves myomectomies with regular follow-up with favourable prognosis. It is important to properly manage these cases to avoid the overdiagnosis and mistreatment not to mention the repercussion of false diagnoses on the patient's mental health and well-being.
子宫平滑肌瘤在育龄女性中很常见。然而,也存在罕见的、不寻常的生长模式,如非典型、富于细胞、有丝分裂活跃、黏液样和上皮样平滑肌瘤,由于它们酷似子宫平滑肌肉瘤等高恶性子宫肿瘤,因而成为一个主要问题。此类病例的一个例子是上皮型平滑肌瘤,我们报告的是一名35岁女性患者的该病例。一名35岁未生育女性因异常子宫出血到急诊科就诊。检查发现一个可疑的子宫肿物,从子宫底部肌壁内部分延伸至宫颈口。患者接受了开放性肌瘤切除术,未出现并发症。最终病理报告显示为一种极其罕见的良性上皮型平滑肌瘤,无恶性病变,有极少非典型区域和低有丝分裂活性(<5/10高倍视野),可见局灶性坏死区域(可能为缺血型)。未发现凝固性肿瘤坏死。子宫平滑肌瘤是子宫的常见病理情况,可能与恶性肿瘤混淆,尤其是在出现不寻常生长模式时,如上皮样平滑肌瘤。明确的治疗方法是肌瘤切除术并定期随访,预后良好。正确处理这些病例很重要,以避免过度诊断和不当治疗,更不用说错误诊断对患者心理健康和幸福的影响了。