Department of Gynecology, Ji Nan Key Laboratory of Diagnosis and Treatment of Major Gynaecological Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.
School of Chemistry and Pharmaceutical Engineering, Medical Science and Technology Innovation Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250000, China.
Adv Sci (Weinh). 2024 Nov;11(44):e2409778. doi: 10.1002/advs.202409778. Epub 2024 Oct 7.
Endometriosis is a prevalent gynecological condition characterized by chronic pelvic pain, dysmenorrhea, and infertility, affecting ≈176 million women of reproductive age worldwide. Current treatments, including pharmacological and surgical interventions, are often associated with significant side effects and high recurrence rates. Consequently, there is an urgent need for innovative and safer therapeutic approaches. In this study, an injectable magnetic hydrogel nanosystem is developed designed for the dual-purpose magnetothermal and anti-inflammatory treatment of endometriosis. This hydrogel incorporates FeO nanoparticles alongside an anti-inflammatory peptide. Upon magnetic activation, the FeO nanoparticles induce a localized hyperthermic response, raising the temperature of endometriotic lesions to 63.3 °C, effectively destroying endometriotic cells. Concurrently, the thermally responsive hydrogel facilitates the controlled release of the anti-inflammatory peptide, thus modulating the inflammatory milieu. The biocompatibility and complete in vivo degradability of the hydrogel further enhance its therapeutic potential. The in vivo studies demonstrated that this injectable magnetic hydrogel system achieved a 90% reduction in the volume of endometriotic lesions and significantly decreased inflammatory markers, offering a promising non-invasive treatment modality for endometriosis. By integrating precise lesion ablation with the modulation of the inflammatory microenvironment, this system represents a novel approach to the clinical management of endometriosis.
子宫内膜异位症是一种常见的妇科疾病，其特征为慢性盆腔疼痛、痛经和不孕，影响全球约 1.76 亿育龄妇女。目前的治疗方法，包括药物和手术干预，往往伴随着显著的副作用和高复发率。因此，迫切需要创新和更安全的治疗方法。在这项研究中，开发了一种可注射的磁性水凝胶纳米系统，用于子宫内膜异位症的磁热和抗炎双重治疗。该水凝胶结合了 FeO 纳米颗粒和一种抗炎肽。在磁性激活后，FeO 纳米颗粒会引起局部过热反应，将子宫内膜异位病灶的温度提高到 63.3°C，有效破坏子宫内膜异位细胞。同时，热响应水凝胶促进抗炎肽的控制释放，从而调节炎症微环境。水凝胶的生物相容性和完全体内可降解性进一步增强了其治疗潜力。体内研究表明，这种可注射的磁性水凝胶系统使子宫内膜异位病灶的体积减少了 90%，并显著降低了炎症标志物，为子宫内膜异位症提供了一种有前途的非侵入性治疗方法。通过将精确的病灶消融与炎症微环境的调节相结合，该系统为子宫内膜异位症的临床管理提供了一种新方法。
