Araki Jun, Okuda Hyougo
Faculty of Textile Science and Technology, Shinshu University, Tokida 3-15-1, Ueda 386-8567, Japan.
Graduate School of Science and Technology, Shinshu University, Tokida 3-15-1, Ueda 386-8567, Japan.
Langmuir. 2024 Oct 22;40(42):22077-22088. doi: 10.1021/acs.langmuir.4c02404. Epub 2024 Oct 7.
Hybrid nanoparticles composed of chitin nanowhiskers (ChNWs) and gold nanoclusters (AuNCs) having an improved stability were prepared. The grafting of monomethoxypoly(ethylene glycol) (mPEG) and subsequent surface adsorption of AuNCs enabled the steric stabilization of ChNW/AuNC hybrids. mPEGs with terminal formyl groups and diethylacetal protecting groups were grafted via in situ deprotection and reductive amination with the surface amino groups (SAGs) of ChNWs. The treatment of chitin with a 30% sodium hydroxide solution improved the SAG contents of the ChNWs obtained from acid hydrolysis, resulting in an enhancement in mPEG grafting. The obtained sterically stabilized ChNW/AuNC hybrids exhibited remarkable dispersion stability at higher AuNC and electrolyte concentrations.
制备了由几丁质纳米晶须（ChNWs）和具有更高稳定性的金纳米团簇（AuNCs）组成的杂化纳米颗粒。单甲氧基聚（乙二醇）（mPEG）的接枝以及随后AuNCs的表面吸附实现了ChNW/AuNC杂化物的空间稳定化。具有末端甲酰基和二乙缩醛保护基团的mPEGs通过原位脱保护和与ChNWs的表面氨基（SAGs）进行还原胺化反应进行接枝。用30%的氢氧化钠溶液处理几丁质提高了酸水解得到的ChNWs的SAG含量，从而提高了mPEG的接枝率。所获得的空间稳定化的ChNW/AuNC杂化物在较高的AuNC和电解质浓度下表现出显著的分散稳定性。
