Dokuz Eylül University Hospital, Department of Dermatology, İzmir, Türkiye.
Dokuz Eylül University Hospital, Department of Infectious Diseases and Clinical Microbiology, İzmir, Türkiye.
Turkiye Parazitol Derg. 2024 Oct 7;48(3):171-177. doi: 10.4274/tpd.galenos.2024.93064.
This study describes the relationships of factors related to gut microbiota and skin conditions associated with , including demodicosis, rosacea, and perioral dermatitis.
A total of 113 patients from Dokuz Eylül University Hospital Dermatology Department answered a cross-sectional questionnaire. They consisted of 42 cases of -related skin diseases and 71 healthy controls. Demographic data and medical history, dietary and lifestyle habits, and gastrointestinal symptoms were recorded. Statistical analysis included descriptive statistics, chi-square tests, Fisher's Exact tests, independent samples t-tests, and logistic regression methods.
Our findings identified alcohol consumption [odds ratio (OR)=11.13, 95% confidence interval (CI): 4.11-17.22, p<0.01] and smoking (OR=10.32, 95% CI: 2.47-21.57, p<0.01) as strong risk factors for -related conditions. Low water intake (0-1 liter per day) (OR=3.39, 95% CI: 2.08-5.57, p=0.03) and infrequent exercise (less than 1 hour per week) (OR=4.87, 95% CI: 2.70-12.54, p=0.02) were also significant risk factors. Additional factors associated with increased risk included reduced bowel movements (OR=2.71, 95% CI: 1.45-4.06, p=0.01) and higher pet ownership (OR=2.85, 95% CI: 2.13-4.27, p=0.03). Although vegetarian and high-fat diets showed some associations, they were not independently significant.
This study demonstrates key environmental and lifestyle factors, such as low water intake, infrequent exercise, reduced bowel movements, higher pet ownership, alcohol consumption, and smoking, that are significantly associated with -related skin conditions. These factors, related to gut microbiota, may provide valuable insights for managing these skin conditions and suggest promising directions for future research.
本研究描述了与 相关的肠道微生物群因素与皮肤状况之间的关系，包括蠕形螨病、酒渣鼻和口周皮炎。
共有 113 名来自多乌-埃夫大学医院皮肤科的患者回答了横断面问卷。他们包括 42 例与 相关的皮肤病和 71 例健康对照。记录人口统计学数据和病史、饮食和生活方式习惯以及胃肠道症状。统计分析包括描述性统计、卡方检验、Fisher 精确检验、独立样本 t 检验和逻辑回归方法。
我们的研究结果发现，饮酒（比值比[OR]=11.13，95%置信区间[CI]：4.11-17.22，p<0.01）和吸烟（OR=10.32，95% CI：2.47-21.57，p<0.01）是与 相关疾病的强烈危险因素。低饮水量（0-1 升/天）（OR=3.39，95% CI：2.08-5.57，p=0.03）和不经常运动（每周少于 1 小时）（OR=4.87，95% CI：2.70-12.54，p=0.02）也是显著的危险因素。与增加 风险相关的其他因素包括减少排便次数（OR=2.71，95% CI：1.45-4.06，p=0.01）和更高的宠物拥有率（OR=2.85，95% CI：2.13-4.27，p=0.03）。尽管素食和高脂肪饮食显示出一些关联，但它们并不具有独立意义。
本研究表明，低饮水量、不经常运动、减少排便次数、更高的宠物拥有率、饮酒和吸烟等关键环境和生活方式因素与 相关的皮肤状况显著相关。这些与肠道微生物群相关的因素可能为管理这些皮肤状况提供有价值的见解，并为未来的研究提供有前途的方向。
