Faculty of Materials Science and Engineering, Phenikaa University, Hanoi, 12116, Vietnam.
Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Vietnam.
Mikrochim Acta. 2024 Oct 7;191(11):652. doi: 10.1007/s00604-024-06682-w.
A flexible, ultrasensitive, and practical SERS chip is presented based on a paper/f-TiO/Ag structure. The chip enhances the self-assembly of Ag nanoparticles on a cellulose fiber matrix, facilitated by smart functionalized TiO nanomaterials (f-TiO). This design enables superior detection of the hazardous pesticide tricyclazole (TCZ) on crops using an advanced, simple, and efficient analytical method. Despite its straightforward fabrication process via a solvent immersion method, the intrinsic smart surface properties of the TiO bridging material - both hydrophilic and hydrophobic - enable the uniform and dense self-assembly of hydrophilic Ag nanoparticles (NPs) on the cellulose fiber paper substrate. This innovative design provides superior sensing efficiency for TCZ molecules with a detection limit reaching 2.1 × 10 M, a remarkable improvement compared to Paper/Ag substrates lacking f-TiO nanomaterials, which register at 10 M. This flexible SERS substrate also exhibits very high reliability as indicated by its excellent reproducibility and repeatability with relative standard deviations (RSD) of only 5.93% and 4.73%, respectively. Characterized by flexibility and a water-attractive yet non-soluble surface, the flexible Paper/f-TiO/Ag chips offer the convenience of direct immersion into the analytical sample, facilitating seamless target molecule collection while circumventing interference signals. Termed the "dip and dry" technique, its advantages in field analysis are indisputable, boasting in situ deployment, simplicity, and high efficiency, while minimizing interference signals to negligible levels. Through the application of this advanced technique, we have successfully detected TCZ in two high-value crops, ST25 rice and dragon fruit, achieving excellent recovery values ranging from 90 to 128%. This underscores its immense potential in ensuring food quality and safety. As a proof of concept, flexible Paper/f-TiO/Ag SERS chips, with a simple fabrication process, advanced analytical technique, and superior sensing efficiency, bring SERS one step closer to field applications beyond the laboratory.
提出了一种基于纸/ f-TiO/Ag 结构的灵活、超灵敏和实用的 SERS 芯片。该芯片通过智能功能化 TiO 纳米材料（f-TiO）促进 Ag 纳米颗粒在纤维素纤维基质上的自组装。该设计使用先进、简单和高效的分析方法，实现了对农作物中危险农药三唑酮（TCZ）的优异检测。尽管通过溶剂浸渍法进行了简单的制造过程，但 TiO 桥接材料的固有智能表面特性——亲水性和疏水性——使亲水性 Ag 纳米颗粒（NPs）在纤维素纤维纸基底上均匀且致密地自组装。这种创新设计为 TCZ 分子提供了卓越的传感效率，检测限达到 2.1×10^-7 M，与缺乏 f-TiO 纳米材料的 Paper/Ag 基底相比有了显著提高，后者的检测限为 10^-6 M。这种灵活的 SERS 基底还表现出非常高的可靠性，其重现性和重复性的相对标准偏差（RSD）分别仅为 5.93%和 4.73%。灵活的 Paper/f-TiO/Ag 芯片具有柔韧性和水亲和但不可溶性表面的特点，提供了直接浸入分析样品的便利性，便于无缝收集目标分子，同时避免干扰信号。这种方法称为“浸和干”技术，其在现场分析中的优势是不可否认的，具有原位部署、简单高效的特点，同时将干扰信号降至可忽略水平。通过应用这种先进技术，我们成功地在两种高价值作物 ST25 水稻和火龙果中检测到 TCZ，实现了 90%至 128%的优异回收率。这突显了其在确保食品质量和安全方面的巨大潜力。作为概念验证，具有简单制造工艺、先进分析技术和卓越传感效率的灵活 Paper/f-TiO/Ag SERS 芯片将 SERS 技术推向了超越实验室的现场应用的一步。
