Pham Anh-Tuan, Bui Hanh Nhung, Mai Quan-Doan, Le Anh-Tuan
Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Viet Nam.
Faculty of Materials Science and Engineering, Phenikaa University, Hanoi, 12116, Viet Nam.
Heliyon. 2023 Sep 7;9(9):e19926. doi: 10.1016/j.heliyon.2023.e19926. eCollection 2023 Sep.
Flexible surface-enhanced Raman scattering (SERS) sensors have gained significant attention for their practical applications in detecting chemical and biological molecules. However, the fabrication of flexible SERS chips is often complex and requires advanced techniques. In this study, we present a simple and rapid method to design a flexible SERS chip based on polyvinyl alcohol (PVA), cellulose, and silver nanoparticles (AgNPs) using mechanical stirring and drying methods. Benefiting from the abundant hydroxide groups on cellulose, AgNPs easily adhere and distribute evenly on the cellulose surface. The combination of PVA and cellulose forms a bendable film-like SERS chip. This chip allows convenient immersion in liquid analyte samples. We demonstrate its effectiveness by using it to detect the thiram pesticide in apple juice using the "dip and dry" method, achieving an outstanding detection limit of 1.01 × 10 M. The Raman signals on the SERS chips exhibit high repeatability and reproducibility, with relative standard deviation values below 10%. These findings show that the flexible PVA/cellulose/Ag SERS chips is a strong candidate for real-world analysis.
柔性表面增强拉曼散射(SERS)传感器因其在检测化学和生物分子方面的实际应用而备受关注。然而,柔性SERS芯片的制造通常很复杂,需要先进的技术。在本研究中,我们提出了一种简单快速的方法,通过机械搅拌和干燥方法,设计一种基于聚乙烯醇(PVA)、纤维素和银纳米颗粒(AgNPs)的柔性SERS芯片。受益于纤维素上丰富的羟基,AgNPs很容易附着并均匀分布在纤维素表面。PVA和纤维素的结合形成了一种可弯曲的薄膜状SERS芯片。该芯片可以方便地浸入液体分析物样品中。我们通过使用“浸入并干燥”方法检测苹果汁中的福美双农药来证明其有效性,实现了1.01×10⁻⁸M的出色检测限。SERS芯片上的拉曼信号具有很高的重复性和再现性,相对标准偏差值低于10%。这些发现表明,柔性PVA/纤维素/Ag SERS芯片是实际分析的有力候选者。