Roth Jenny, Toprak Baris, Somajo Sofia, Macedo Antonio Filipe, Lagali Neil
Department of Medicine and Optometry, Linnaeus University, Kalmar, 39182, Sweden.
Department of Biomedical and Clinical Sciences, Faculty of Medicine, Linköping University, Linköping, 581 83, Sweden.
J Ophthalmic Inflamm Infect. 2024 Oct 7;14(1):49. doi: 10.1186/s12348-024-00432-y.
The aim of this study was to characterize bacterial species, aetiology and antibiotic susceptibility connected to bacterial keratitis infections in Östergötland, Sweden.
Retrospective cross-sectional study based on electronic health records for the period 2010-2019. Records of patients diagnosed with infectious keratitis were screened for microbiology confirmed infectious bacterial keratitis. Bacterial species and their susceptibility to antibiotics were determined from microbiology test results.
One-hundred and ninety patients with lab culture-confirmed infectious bacterial keratitis were included in the analysis. The most frequently found bacterial species were coagulase-negative staphylococci (39%), Staphylococcus aureus (17%) and Cutibacterium acnes (10%). Pseudomonas spp. was the most frequently found Gram-negative bacterial species (7%). Contact lens wear and severely ill/blind eye were the top two aetiologies associated with bacterial keratitis, 22% of the patients with bacterial keratitis were also diagnosed with glaucoma. Most isolates, 157 out of 173, were susceptible to fluoroquinolones, and 145 out of 155 isolates were susceptible to chloramphenicol.
Our results revealed a positive rate of bacterial keratitis of 59% for the samples sent to the laboratory. There was a high susceptibility of the bacterial species to the recommended antibiotics. Our results indicate that it is likely that patients are receiving the correct treatment. Future studies are necessary to monitor changes in antibiotic susceptibility.
本研究旨在描述瑞典东约特兰地区与细菌性角膜炎感染相关的细菌种类、病因及抗生素敏感性。
基于2010年至2019年期间的电子健康记录进行回顾性横断面研究。对诊断为感染性角膜炎的患者记录进行筛查，以确定微生物学确诊的感染性细菌性角膜炎。根据微生物学检测结果确定细菌种类及其对抗生素的敏感性。
190例经实验室培养确诊的感染性细菌性角膜炎患者纳入分析。最常见的细菌种类为凝固酶阴性葡萄球菌（39%）、金黄色葡萄球菌（17%）和痤疮丙酸杆菌（10%）。铜绿假单胞菌是最常见的革兰氏阴性菌（7%）。佩戴隐形眼镜和重症/盲眼是与细菌性角膜炎相关的前两大病因，22%的细菌性角膜炎患者还被诊断为青光眼。在173株分离菌株中，大多数（157株）对氟喹诺酮类药物敏感，在155株分离菌株中，145株对氯霉素敏感。
我们的结果显示，送检样本的细菌性角膜炎阳性率为59%。这些细菌种类对推荐抗生素的敏感性较高。我们的结果表明患者可能正在接受正确的治疗。未来有必要开展研究以监测抗生素敏感性的变化。
