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使用头孢地尔成功治疗一名患有嗜麦芽窄食单胞菌医院获得性肺炎的新生儿。

Successful therapy of a newborn with Stenotrophomonas maltophilia nosocomial pneumonia with cefiderocol.

作者信息

Trauth Janina, Schuler Rahel, Waitz Markus, Ehrhardt Harald, Fritzenwanker Moritz, Herold Susanne

机构信息

Department of Medicine V - Internal Medicine, Infectious Diseases & Infection Control, Justus- Liebig-University, member of the German Center for Lung Research (DZL) and German Center for Infection Research (DZIF) and Cardio-Pulmonary Institute (CPI), Giessen, Germany.

Department of General Pediatrics and Neonatology, Justus Liebig University, Giessen, Germany.

出版信息

Infection. 2025 Jun;53(3):1227-1231. doi: 10.1007/s15010-024-02404-9. Epub 2024 Oct 7.

DOI:10.1007/s15010-024-02404-9
PMID:39373949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12137400/
Abstract

Cefiderocol is a new siderophore-beta-lactam antibiotic used for the treatment of severe multidrug-resistant infections like sepsis, hospital-acquired and ventilator-associated pneumonia in adults, but there are only single reports on its use in the neonatal population. We describe the successful cefiderocol treatment of a newborn with pneumogenic sepsis due to Stenotrophomonas maltophilia.

摘要

头孢地尔是一种新型的铁载体β-内酰胺类抗生素，用于治疗严重的多重耐药感染，如成人败血症、医院获得性肺炎和呼吸机相关性肺炎，但关于其在新生儿群体中的应用仅有个别报道。我们描述了一例因嗜麦芽窄食单胞菌导致肺源性败血症的新生儿成功接受头孢地尔治疗的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa3/12137400/a53392b135ef/15010_2024_2404_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa3/12137400/a53392b135ef/15010_2024_2404_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fa3/12137400/a53392b135ef/15010_2024_2404_Fig1_HTML.jpg

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本文引用的文献

1
Infectious Diseases Society of America 2024 Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.美国传染病学会2024年抗微生物药物耐药革兰氏阴性菌感染治疗指南
Clin Infect Dis. 2024 Aug 7. doi: 10.1093/cid/ciae403.
2
Global prevalence of cefiderocol non-susceptibility in Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia: a systematic review and meta-analysis.全球肠杆菌科、铜绿假单胞菌、鲍曼不动杆菌和嗜麦芽寡养单胞菌对头孢地尔罗耐药的流行情况：系统评价和荟萃分析。
Clin Microbiol Infect. 2024 Feb;30(2):178-188. doi: 10.1016/j.cmi.2023.08.029. Epub 2023 Sep 4.
3
Successful Use of Cefiderocol to Treat a Multidrug-resistant Stenotrophomonas maltophilia Ventilator-associated Pneumonia in an Extremely Preterm Neonate.
成功使用头孢地尔治疗极早产儿耐多药嗜麦芽窄食单胞菌呼吸机相关性肺炎
Pediatr Infect Dis J. 2023 Nov 1;42(11):1012-1016. doi: 10.1097/INF.0000000000004051. Epub 2023 Jul 24.
4
New Antimicrobials for the Treatment of Neonatal Sepsis Caused by Multi-Drug-Resistant Bacteria: A Systematic Review.用于治疗多重耐药菌引起的新生儿败血症的新型抗菌药物：一项系统评价
Antibiotics (Basel). 2023 May 24;12(6):956. doi: 10.3390/antibiotics12060956.
5
Cefiderocol as Salvage Therapy for Carbapenem-Resistant Klebsiella pneumoniae Sepsis in an Extremely Preterm Neonate.头孢地尔作为挽救治疗用于极低出生体重早产儿耐碳青霉烯类肺炎克雷伯菌败血症
Indian J Pediatr. 2023 Mar;90(3):310. doi: 10.1007/s12098-022-04468-7. Epub 2023 Jan 13.
6
Bloodstream Infection Due to a VIM-Metallo-β-Lactamase-Producing Klebsiella pneumoniae Treated with Cefiderocol in a Preterm Newborn.用头孢地尔治疗的早产新生儿中，由产VIM金属β-内酰胺酶的肺炎克雷伯菌引起的血流感染
Infect Dis Ther. 2023 Feb;12(2):727-734. doi: 10.1007/s40121-022-00735-4. Epub 2022 Dec 15.
7
Antibiotics needed to treat multidrug-resistant infections in neonates.用于治疗新生儿多重耐药感染的抗生素。
Bull World Health Organ. 2022 Dec 1;100(12):797-807. doi: 10.2471/BLT.22.288623. Epub 2022 Oct 3.
8
[Clinical experience using cefiderocol].[使用头孢地尔的临床经验]
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Microbiol Spectr. 2022 Apr 27;10(2):e0271221. doi: 10.1128/spectrum.02712-21. Epub 2022 Mar 9.
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Cefiderocol for the Treatment of Infections Due to Metallo-B-lactamase-Producing Pathogens in the CREDIBLE-CR and APEKS-NP Phase 3 Randomized Studies.头孢地尔在 CREDIBLE-CR 和 APEKS-NP 三期随机研究中治疗产金属β-内酰胺酶病原体感染。
Clin Infect Dis. 2022 Sep 29;75(6):1081-1084. doi: 10.1093/cid/ciac078.