Division of Endocrinology and Molecular Medicine, Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA; Cardiovascular Research Center, Division of Endocrinology and Molecular Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Division of Endocrinology and Molecular Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
J Lipid Res. 2024 Nov;65(11):100664. doi: 10.1016/j.jlr.2024.100664. Epub 2024 Oct 5.
Procollagen C-endopeptidase enhancer 2, known as PCPE2 or PCOC2 (gene name, PCOLCE2) is a glycoprotein that resides in the extracellular matrix, and is similar in domain organization to PCPE1/PCPE, PCOC1 (PCOLCE1/PCOLCE). Due to the many similarities between the two related proteins, PCPE2 has been assumed to have biological functions similar to PCPE. PCPE is a well-established enhancer of procollagen processing activating the enzyme, BMP-1. However, reports show that PCPE2 has a strikingly different tissue expression profile compared to PCPE. With that in mind and given the paucity of published studies on PCPE2, this review examines the current literature citing PCPE2 and its association with specific cell types and signaling pathways. Additionally, this review will present a brief history of PCPE2's discovery, highlighting structural and functional similarities and differences compared to PCPE. Considering the widespread use of RNA sequencing techniques to examine associations between cell-specific gene expression and disease states, we will show that PCPE2 is repeatedly found as a differentially regulated gene (DEG) significantly associated with a number of cellular processes, well beyond the scope of procollagen fibril processing.
原胶原蛋白 C 端肽酶增强子 2，也被称为 PCPE2 或 PCOC2（基因名称，PCOLCE2），是一种位于细胞外基质中的糖蛋白，其结构域组织与 PCPE1/PCPE、PCOC1（PCOLCE1/PCOLCE）相似。由于这两种相关蛋白之间有许多相似之处，因此假设 PCPE2 具有与 PCPE 相似的生物学功能。PCPE 是一种成熟的前胶原加工增强子，可激活酶 BMP-1。然而，报告显示 PCPE2 的组织表达谱与 PCPE 有很大的不同。考虑到关于 PCPE2 的研究很少，这篇综述检查了引用 PCPE2 及其与特定细胞类型和信号通路关联的现有文献。此外，这篇综述将简要介绍 PCPE2 的发现历史，重点介绍与 PCPE 相比其结构和功能的相似性和差异。考虑到 RNA 测序技术广泛用于研究特定细胞基因表达与疾病状态之间的关联，我们将表明 PCPE2 是一个经常被发现的差异调节基因（DEG），与许多细胞过程显著相关，远远超出了原胶原纤维加工的范围。
